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Table 6 Amino acid analysis of maternal plasma at week-15 and week-32 of gestation

From: Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

Week-32 of gestation (P32)

Amino acid levels

(μmol/L)

Control group

n-3 LCPUFA intervention group

P-values regression

Con-F (n = 10)

Con-M (n = 9)

N3-F (n = 10)

N3-M (n = 10)

Treatment

Sex

Interaction

Con-M

vs

Con-F

N3-M

vs

N3-F

N3-F

vs

Con-F

N3-M

vs

Con-M

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Tau

98.95

(76.60–122.08)

105.70

(90.75–118.25)

92.90

(89.18–103.93)

78.55

(70.45–88.95)

0.027

0.425

0.285

0.830

0.191

0.376

0.023

His

80.70

(72.05–83.68)

74.80

(65.80–76.55)

76.60

(72.28–80.85)

74.70

(68.93–82.35)

0.979

0.650

0.433

0.387

0.829

0.603

0.561

Val

155.20

(140.20–176.68)

149.10

(140.45–158.75)

163.25

(132.05–179.73)

156.20

(131.55–172.65)

0.696

0.697

0.683

0.576

0.983

0.985

0.575

Met

9.20

(8.50–10.65)

9.20

(7.75–10.65)

8.90

(7.73–10.93)

10.25

(8.70–11.00)

0.422

0.425

0.592

0.865

0.348

0.842

0.349

Tyr

31.25

(29.65–35.98)

32.80

(29.60–38.45)

36.45

(33.45–39.50)

32.15

(29.23–37.08)

0.189

0.803

0.508

0.521

0.755

0.166

0.687

Ile

42.30

(32.90–45.23)

36.70

(33.55–46.45)

41.30

(39.18–45.33)

38.80

(34.87–43.65)

0.965

0.546

0.918

0.726

0.618

0.919

0.968

Leu

71.45

(66.05–75.33)

67.10

(62.60–83.05)

79.95

(72.95–82.90)

73.85

(63.98–78.45)

0.269

0.558

0.640

0.929

0.461

0.271

0.646

Phe

37.25

(34.65–38.95)

38.10

(33.15–39.05)

39.60

(38.58–42.08)

38.45

(35.20–40.85)

0.063

0.556

0.428

0.912

0.329

0.065

0.459

Trp

35.05

(32.78–39.05)

37.40

(35.05–42.35)

42.70

(40.60–45.28)

39.85

(34.05–44.53)

0.004

0.613

0.225

0.225

0.596

0.004

0.217

Week-15 of gestation (P15 = baseline)

Amino acid levels

(μmol/L)

Control group

n-3 LCPUFA intervention group

P-values regression

Con-F (n = 11)

Con-M (n = 9)

N3-F (n = 10)

N3-M (n = 11)

Sex

      

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Tau

106.50

(67.60–131.10)

110.60

(103.60–142.85)

108.40

(66.45–131.03)

108.70

(92.20–142.30)

0.175

      

His

68.80

(64.60–76.60)

69.30

(61.45–73.40)

70.95

(63.68–75.88)

62.50

(59.90–66.70)

0.059

      

Val

168.30

(157.20–191.60)

172.40

(146.00–185.05)

184.55

(159.20–208.55)

160.30

(145.00–178.50)

0.061

      

Met

8.70

(8.00–11.60)

9.20

(8.20–10.10)

9.80

(8.83–11.95)

10.00

(9.50–10.10)

0.612

      

Tyr

33.30

(29.40–37.70)

36.50

(32.75–40.85)

36.10

(31.38–41.83)

30.20

(27.20–34.60)

0.178

      

Ile

38.50

(37.30–42.90)

38.70

(37.65–40.50)

43.25

(37.88–49.55)

40.70

(37.40–45.30)

0.260

      

Leu

80.40

(76.90–84.20)

80.40

(70.60–86.30)

86.20

(77.55–92.45)

81.20

(72.00–91.10)

0.234

      

Phe

39.00

(36.70–43.90)

39.20

(36.70–41.10)

40.70

(38.28–46.65)

37.40

(36.30–40.40)

0.051

      

Trp

41.30

(39.20–46.30)

44.00

(40.70–50.40)

45.40

(42.35–51.38)

42.00

(36.10–47.40)

0.274

      
  1. Amino acid data are summarized as median (25th centile - 75th centile). For the analyses at P32, the p-values for Treatment and Sex are from linear regression models fit to the amino acid data without a Sex-Group Interaction term. The p-values for the Interaction and pairwise group comparisons are from regression models including a Sex-Group Interaction term. The regression models were adjusted for the respective baseline (P15) levels. For P15, the p-values for Treatment are from simple linear regression models with Treatment as the predictor variable. Two-sided p < 0.05 are marked in bold
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BMC Molecular and Cell Biology

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