Fig. 4
From: CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression
CREB1 overexpression enhanced melanoma cell viability by inhibiting miR-495-3p transcription. A qRT‒PCR detected miR-495-3p levels after A375 and B16 cells were transfected with oe-CREB1. B EdU assays detected A375 and B16 cell viability. C-D Transwell assays detected A375 and B16 cell migration and invasion. E Flow cytometry detected cell apoptosis. The mean ± standard deviation represents data from three independent trials (n = 3). *p < 0.05, ** p < 0.01, *** p < 0.001 (n = 3)