Fig. 6
From: CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression
CREB1 regulated KPNA2 by inhibiting miR-495-3p transcription to enhance melanoma cell viability. A miR-495-3p and KPNA2 mRNA levels were detected after CREB1-overexpressing A375 and B16 cells were transfected with miR-495-3p mimics or miR-495-3p-overexpressing A375 and B16 cells were transfected with oe-KPNA2. B EdU assays detected A375 and B16 cell viability. C-D Transwell assays detected A375 and B16 cell migration and invasion. E Flow cytometry detected apoptosis. The mean ± standard deviation represents data from three independent trials (n = 3). *p < 0.05, ** p < 0.01, *** p < 0.001 (n = 3)