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  1. Norrin is a potent Wnt pathway ligand. Aberrant activation of this signaling pathway can result in colon tumors but the role of norrin-based signaling in the genesis of colon cancer, and its relationship to ac...

    Authors: Kestutis Planutis, Marina Planutiene, Mary Pat Moyer, Anthony V Nguyen, Cherlyn A Pérez and Randall F Holcombe
    Citation: BMC Cell Biology 2007 8:12
  2. When exposed to oxidative conditions, cells suffer not only biochemical alterations, but also morphologic changes. Oxidative stress is a condition induced by some pro-oxidant compounds, such as by tert-butylhy...

    Authors: Vilma A Sardão, Paulo J Oliveira, Jon Holy, Catarina R Oliveira and Kendall B Wallace
    Citation: BMC Cell Biology 2007 8:11
  3. The lymphatic system complements the blood circulatory system in absorption and transport of nutrients, and in the maintenance of homeostasis. Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angio...

    Authors: Vicky PKH Nguyen, Stephen H Chen, Jason Trinh, Harold Kim, Brenda L Coomber and Daniel J Dumont
    Citation: BMC Cell Biology 2007 8:10
  4. Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 ac...

    Authors: Øystein L Holla, Jamie Cameron, Knut Erik Berge, Trine Ranheim and Trond P Leren
    Citation: BMC Cell Biology 2007 8:9
  5. CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fractio...

    Authors: Barbara Ulmasov, Jonathan Bruno, Philip G Woost and John C Edwards
    Citation: BMC Cell Biology 2007 8:8
  6. Bcl-2 homology domain (BH) 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to the mitochondrial cell death pathways. The BH3-only protein Bid can be activated in respo...

    Authors: Hans-Georg König, Markus Rehm, Daniel Gudorf, Stan Krajewski, Atan Gross, Manus W Ward and Jochen HM Prehn
    Citation: BMC Cell Biology 2007 8:7
  7. Recombinant adenovirus vectors and transfection agents comprising cationic lipids are widely used as gene delivery vehicles for functional expression in cultured cells. Consequently, these tools are utilized t...

    Authors: Monica Andersson, Malin Warolén, Joakim Nilsson, Martin Selander, Catharina Sterky, Katrin Bergdahl, Christina Sörving, Stephen R James and Magnus Doverskog
    Citation: BMC Cell Biology 2007 8:6
  8. The main role of the chromosomal passenger complex is to ensure that Aurora B kinase is properly localized and activated before and during mitosis. Borealin, a member of the chromosomal passenger complex, show...

    Authors: Harpreet Kaur, Andrew C Stiff, Dipali A Date and William R Taylor
    Citation: BMC Cell Biology 2007 8:5
  9. The four highly homologous human EHD proteins (EHD1-4) form a distinct subfamily of the Eps15 homology domain-containing protein family and are thought to regulate endocytic recycling. Certain members of this ...

    Authors: Manju George, GuoGuang Ying, Mark A Rainey, Aharon Solomon, Pankit T Parikh, Qingshen Gao, Vimla Band and Hamid Band
    Citation: BMC Cell Biology 2007 8:3
  10. Connective tissue growth factor (CTGF) is a potent profibrotic factor, which is implicated in fibroblast proliferation, angiogenesis and extracellular matrix (ECM) synthesis. It is a downstream mediator of som...

    Authors: Xiaojing Liu, Fengming Luo, Kejian Pan, Wenchao Wu and Huaiqing Chen
    Citation: BMC Cell Biology 2007 8:1
  11. Aspartyl (asparaginyl)-β-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation. This study examines the expression, re...

    Authors: Stephanie A Lahousse, Jade J Carter, Xaolai J Xu, Jack R Wands and Suzanne M de la Monte
    Citation: BMC Cell Biology 2006 7:41
  12. 2-Chloroethyl ethyl sulphide (CEES) is a sulphur vesicating agent and an analogue of the chemical warfare agent 2,2'-dichlorodiethyl sulphide, or sulphur mustard gas (HD). Both CEES and HD are alkylating agent...

    Authors: Min Qui, Victor M Paromov, Hongsong Yang, Milton Smith and William L Stone
    Citation: BMC Cell Biology 2006 7:39
  13. The nuclear lamina is a protein meshwork lining the inner nuclear membrane, which contains a polymer of nuclear lamins associated with transmembrane proteins of the inner nuclear membrane. The lamina is involv...

    Authors: I-Hsiung Brandon Chen, Michael Huber, Tinglu Guan, Anja Bubeck and Larry Gerace
    Citation: BMC Cell Biology 2006 7:38
  14. Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation ...

    Authors: Petra Lynen Jansen, Raphael Rosch, Melanie Rezvani, Peter R Mertens, Karsten Junge, Marc Jansen and Uwe Klinge
    Citation: BMC Cell Biology 2006 7:36
  15. CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers. Many CtBP-regulated proteins are involve...

    Authors: Lee M Bergman, Laila Morris, Matthew Darley, Alexander H Mirnezami, Samal C Gunatilake and Jeremy P Blaydes
    Citation: BMC Cell Biology 2006 7:35
  16. HC11 mouse mammary epithelial cells differentiate in response to lactogenic hormone resulting in expression of milk proteins including β-casein. Previous studies have shown that epidermal growth factor (EGF) b...

    Authors: Traci Galbaugh, Maria Grazia Cerrito, Cynthia C Jose and Mary Lou Cutler
    Citation: BMC Cell Biology 2006 7:34
  17. The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recen...

    Authors: Ke Yang, Yang Guo, William C Stacey, Jyoti Harwalkar, Jonathan Fretthold, Masahiro Hitomi and Dennis W Stacey
    Citation: BMC Cell Biology 2006 7:33
  18. DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA ...

    Authors: Erin E Baschal, Kuan J Chen, Lee G Elliott, Matthew J Herring, Shawn C Verde and Tom D Wolkow
    Citation: BMC Cell Biology 2006 7:32
  19. Transcription is regulated by a complex interaction of activators and repressors. The effectors of repression are large multimeric complexes which contain both the repressor proteins that bind to transcription...

    Authors: Xin-Min Zhang, Qing Chang, Lin Zeng, Judy Gu, Stuart Brown and Ross S Basch
    Citation: BMC Cell Biology 2006 7:31
  20. There is a growing interest in cord blood as a source of primitive stem cells with the capacity for multilineage differentiation. Pure cell fractions are needed for the characterization and in vitro expansion of ...

    Authors: Tuija Kekarainen, Sirkka Mannelin, Jarmo Laine and Taina Jaatinen
    Citation: BMC Cell Biology 2006 7:30
  21. Hyperplasia of usual type (HUT) is a common proliferative lesion associated with a slight elevated risk for subsequent development of breast cancer. Cell cycle-related proteins would be helpful to determine th...

    Authors: Luciene SA Tafuri, Gislene FS Rocha and Helenice Gobbi
    Citation: BMC Cell Biology 2006 7:29
  22. The Wnt signaling pathway regulates many processes during embryonic development, including axis specification, organogenesis, angiogenesis, and stem cell proliferation. Wnt signaling has also been implicated i...

    Authors: Jeremy T Blitzer and Roel Nusse
    Citation: BMC Cell Biology 2006 7:28
  23. The present study was carried out to determine whether the p53 pathway played a role in the spontaneous immortalization of the SC-2 chicken embryo fibroblast (CEF) cell line that has been in continuous culture...

    Authors: Shelly A Christman, Byung-Whi Kong, Megan M Landry, Hyunggee Kim and Douglas N Foster
    Citation: BMC Cell Biology 2006 7:27
  24. Studying mitosis requires a system in which the dramatic movements of chromosomes and spindle microtubules can be visualized. PtK cells, due to their flat morphology and their small number of large chromosomes...

    Authors: Jane R Stout, Rania S Rizk, Susan L Kline and Claire E Walczak
    Citation: BMC Cell Biology 2006 7:26
  25. Single-cell level studies are being used increasingly to measure cell properties not directly observable in a cell population. High-performance data acquisition systems for such studies have, by necessity, dev...

    Authors: Kiyoshi Ohnuma, Tetsuya Yomo, Makoto Asashima and Kunihiko Kaneko
    Citation: BMC Cell Biology 2006 7:25
  26. Integrins comprise a large family of α,β heterodimeric, transmembrane cell adhesion receptors that mediate diverse essential biological functions. Higher vertebrates possess a single β1 gene, and the β1 subuni...

    Authors: A Paul Mould, Jennifer A McLeish, Julie Huxley-Jones, Alexander C Goonesinghe, Adam FL Hurlstone, Raymond P Boot-Handford and Martin J Humphries
    Citation: BMC Cell Biology 2006 7:24
  27. There exists abundant molecular and ultra-structural evidence to suggest that cytoplasmic actin can physically interact with the nuclear envelope (NE) membrane system. However, this interaction has yet to be c...

    Authors: Sylvia Münter, Jost Enninga, Rafael Vazquez-Martinez, Erwan Delbarre, Brigitte David-Watine, Ulf Nehrbass and Spencer L Shorte
    Citation: BMC Cell Biology 2006 7:23
  28. The pim family genes encode oncogenic serine/threonine kinases which in hematopoietic cells have been implicated in cytokine-dependent signaling as well as in lymphomagenesis, especially in cooperation with other...

    Authors: Teija LT Aho, Jouko Sandholm, Katriina J Peltola, Yoshiaki Ito and Päivi J Koskinen
    Citation: BMC Cell Biology 2006 7:21
  29. The absorptive and goblet cells are the main cellular types encountered in the intestine epithelium. The cell lineage Caco-2 is a model commonly used to reproduce the features of the bowel epithelium. However,...

    Authors: Géraldine Nollevaux, Christelle Devillé, Benaïssa El Moualij, Willy Zorzi, Patricia Deloyer, Yves-Jacques Schneider, Olivier Peulen and Guy Dandrifosse
    Citation: BMC Cell Biology 2006 7:20
  30. Gene transcriptional activity is well correlated with intra-nuclear position, especially relative to the nuclear periphery, which is a region classically associated with gene silencing. Recently however, activ...

    Authors: David A Drubin, Arman M Garakani and Pamela A Silver
    Citation: BMC Cell Biology 2006 7:19
  31. Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in mo...

    Authors: Olivier Hagens, Andrea Ballabio, Vera Kalscheuer, Jean-Pierre Kraehenbuhl, M Vittoria Schiaffino, Peter Smith, Olivier Staub, Jeff Hildebrand and John B Wallingford
    Citation: BMC Cell Biology 2006 7:18
  32. Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood. As nitric oxide is involved in angiogenesis, we speculate...

    Authors: KP Tamilarasan, Gopi Krishna Kolluru, Megha Rajaram, M Indhumathy, R Saranya and Suvro Chatterjee
    Citation: BMC Cell Biology 2006 7:17
  33. In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides di...

    Authors: Gudrun Valdimarsdottir, Marie-José Goumans, Fumiko Itoh, Susumu Itoh, Carl-Henrik Heldin and Peter ten Dijke
    Citation: BMC Cell Biology 2006 7:16
  34. Transforming Growth Factor-β (TGF-β) regulates key biological processes during development and in adult tissues and has been implicated in many diseases. To study the biological functions of TGF-β, sensitive, ...

    Authors: Ina Tesseur, Kun Zou, Elisabeth Berber, Hui Zhang and Tony Wyss-Coray
    Citation: BMC Cell Biology 2006 7:15
  35. A hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow (BM) necessitates their in vitro expansion prior...

    Authors: Mandana Mohyeddin Bonab, Kamran Alimoghaddam, Fatemeh Talebian, Syed Hamid Ghaffari, Ardeshir Ghavamzadeh and Behrouz Nikbin
    Citation: BMC Cell Biology 2006 7:14
  36. Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional complex (AJC) which regulates cell-cell adhesion, paracellular permeability and cell polarity. The AJC is anchored on cytosk...

    Authors: Andrei I Ivanov, Ingrid C McCall, Brian Babbin, Stanislav N Samarin, Asma Nusrat and Charles A Parkos
    Citation: BMC Cell Biology 2006 7:12
  37. Cell differentiation has long been theorized to represent a switch in a bistable system, and recent experimental work in micro-organisms has revealed bistable dynamics in small gene regulatory circuits. Howeve...

    Authors: Hannah H Chang, Philmo Y Oh, Donald E Ingber and Sui Huang
    Citation: BMC Cell Biology 2006 7:11
  38. Notch plays a wide-ranging role in controlling cell fate, differentiation and development. The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, pr...

    Authors: Grahame Mckenzie, George Ward, Yvette Stallwood, Emmanuel Briend, Sofia Papadia, Andrew Lennard, Martin Turner, Brian Champion and Giles E Hardingham
    Citation: BMC Cell Biology 2006 7:10
  39. The biochemical bases for hormone dependence in breast cancer have been recognized as an important element in tumor resistance, proliferation and metastasis. On this respect, dexamethasone (Dex) dependent prot...

    Authors: Catalina Machuca, Criselda Mendoza-Milla, Emilio Córdova, Salvador Mejía, Luis Covarrubias, José Ventura and Alejandro Zentella
    Citation: BMC Cell Biology 2006 7:9
  40. In human pancreatic cancer progression, the α6β1-integrin is expressed on cancer cell surface during invasion and metastasis formation. In this study, we investigated whether interleukin (IL)-1α induces the alter...

    Authors: Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama and Tadao Manabe
    Citation: BMC Cell Biology 2006 7:8
  41. The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells....

    Authors: Olga P Ryabinina, Ezhilkani Subbian and Mihail S Iordanov
    Citation: BMC Cell Biology 2006 7:7
  42. Despite the great advances in the understanding of programmed cell death, little attention has been paid to the sequence of the events that characterise it. In particular, the course of apoptotic events induce...

    Authors: Francesco Fabbri, Silvia Carloni, Giovanni Brigliadori, Wainer Zoli, Rosa Lapalombella and Marina Marini
    Citation: BMC Cell Biology 2006 7:6
  43. Cutaneous wound repair in adult mammals does not regenerate the original epithelial architecture and results in altered skin function. We propose that lack of regeneration may be due to the absence of appropri...

    Authors: Carrie Fathke, Lynne Wilson, Kavita Shah, Brian Kim, Anne Hocking, Randall Moon and Frank Isik
    Citation: BMC Cell Biology 2006 7:4

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