Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte C, Witte MH, Jackson D, Suri C, Campochiaro PA, Wiegand SJ, Yancopoulos GD: Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Developmental Cell. 2002, 3: 411-423. 10.1016/S1534-5807(02)00217-4.
Article
CAS
PubMed
Google Scholar
Morisada T, Oike Y, Yamada Y, Urano T, Akao M, Kubota Y, Maekawa H, Kimura Y, Ohmura M, Miyanoto T, Nozawa S, Koh GY, Alitalo K, Suda T: Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood. 2005, 105 (12): 4659-4656. 10.1182/blood-2004-08-3382.
Article
Google Scholar
Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmen C, Oike Y, Pajusola K, Thurston G, Suda T, Yla-Herttuala S, Alitalo K: Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 2005, 105 (12): 4642-4648. 10.1182/blood-2004-08-3327.
Article
CAS
PubMed
Google Scholar
Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD: Requisite role of angiopoietin-1, a ligand for the Tie-2 receptor, during embryonic angiogenesis. Cell. 1996, 87 (7): 1171-1180. 10.1016/S0092-8674(00)81813-9.
Article
CAS
PubMed
Google Scholar
Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD: Angiopoietin-2, a natural antagonist for Tie-2 that disrupts in vivo angiogenesis. Science. 1997, 277: 55-60. 10.1126/science.277.5322.55.
Article
CAS
PubMed
Google Scholar
Kim I, Kim JH, Moon SO, Kwak HJ, Kim N-G, Koh GY: Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. Oncogene. 2000, 19: 4549-4552. 10.1038/sj.onc.1203800.
Article
CAS
PubMed
Google Scholar
Teichert-Kuliszewska K, Maisonpierre PC, Jones N, Campbell AI, Master Z, Bendeck MP, Alitalo K, Dumont DJ, Yancopoulos GD, Stewart DJ: Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie-2. Cardiovascular Research. 2001, 49: 659-670. 10.1016/S0008-6363(00)00231-5.
Article
CAS
PubMed
Google Scholar
Mochizuki Y, Nakamura T, Kanetake H, Kanda S: Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. Journal of Cell Science. 2002, 115: 175-183.
CAS
PubMed
Google Scholar
Harfouche R, Hussain SN: Signalling and regulation of endothelial cell survival by angiopoietin-2. Am J Physiol Heart Circ Physiol. 2006, 291 (4): H1635-1645. 10.1152/ajpheart.01318.2005.
Article
CAS
PubMed
Google Scholar
Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO: Direct cell adhesion to the angiopoietins mediated by integrins. Journal of Biological Chemistry. 2001, 276: 26516-26625. 10.1074/jbc.M100282200.
Article
CAS
PubMed
Google Scholar
Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT: Dysmorphogenesis of kidney cortical peritubular capillaries in Angiopoietin-2-deficient mice. American Journal of Pathology. 2004, 165 (6): 1896-1906.
Article
Google Scholar
Hackett SF, Wiegand S, Yancopoulos G, Campochiaro PA: Angiopoietin-2 plays an important role in retinal angiogenesis. Journal of Cellular Physiology. 2002, 192: 182-187. 10.1002/jcp.10128.
Article
CAS
PubMed
Google Scholar
Leak LV, Jones M: Lymphatic endothelium isolation, characterization and long term culture. The Anatomical Record. 1993, 236: 641-652. 10.1002/ar.1092360408.
Article
CAS
PubMed
Google Scholar
Johnston MG, Walker MA: Lymphatic endothelial and smooth-muscle cells in tissue culture. In Vitro. 1984, 20 (7): 566-570.
Article
CAS
PubMed
Google Scholar
Gordon J: Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods in Enzymology. 1991, 201: 477-482.
Article
CAS
PubMed
Google Scholar
Tammela T, Petrova TV, Alitalo K: Molecular lymphangiogenesis: new players. Trends in Cell Biology. 2005, 15 (8): 434-441. 10.1016/j.tcb.2005.06.004.
Article
CAS
PubMed
Google Scholar
Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G: Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. Mechanisms of Development. 2001, 109: 115-119. 10.1016/S0925-4773(01)00518-4.
Article
CAS
PubMed
Google Scholar
Barton WA, Tzvetkova-Robev D, Miranda EP, Kolev MV, Rajashankar KR, Himanen JP, Nikolov DB: Crystal structures of the Tie-2 receptor ectodomain and the angiopoietin-2-Tie-2 complex. Nature Structural and Molecular Biology. 2006, 13: 524-532. 10.1038/nsmb1101.
Article
CAS
PubMed
Google Scholar
Bogdanovic E, Nguyen VP, Dumont DJ: Activation of Tie-2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. Journal of Cell Science. 2006, 119: 1551-1560. 10.1242/jcs.03077.
Article
Google Scholar
Yoon MJ, Cho CH, Lee CS, Jang IH, Ryu SH, Koh GY: Localization of Tie-2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells. Biochemical Biophysics Research Communications. 2003, 308 (1): 101-105. 10.1016/S0006-291X(03)01341-X.
Article
CAS
Google Scholar
Kanda S, Miyata Y, Mochizuki Y, Matsuyama T, Kanetake H: Angiopoietin 1 is mitogenic for cultured endothelial cells. Cancer Research. 2005, 65 (15): 6820-6827. 10.1158/0008-5472.CAN-05-0522.
Article
CAS
PubMed
Google Scholar
Hu B, Jarzynka MJ, Guo P, Imanishi Y, Schlaepfer DD, Cheng SY: Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signalling pathway. Cancer Research. 2006, 66 (2): 775-783. 10.1158/0008-5472.CAN-05-1149.
Article
PubMed Central
CAS
PubMed
Google Scholar
Murray BW, Padrique ES, Pinko C, McTique MA: Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie-2 and phospho-Tie-2. Biochemistry. 2001, 40: 10243-10253. 10.1021/bi010959e.
Article
CAS
PubMed
Google Scholar
Witzenbichler B, Maisonpierre PC, Jones P, Yancopoulos GD, Isner JM: Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie-2. Journal of Biological Chemistry. 1998, 273 (29): 18514-18521. 10.1074/jbc.273.29.18514.
Article
CAS
PubMed
Google Scholar
Liu W, Reinmuth N, Stoeltzing O, Parikh AA, Fan F, Ahmad SA, Jung YD, Ellis LM: Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Seminaries in Oncology. 2002, 29 (3 Suppl 11): 96-103. 10.1053/sonc.2002.34061.
Article
CAS
Google Scholar
Hayes AJ, Huang WQ, Mallah J, Yang D, Lippman ME, Li LY: Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvascular Research. 1999, 58: 224-237. 10.1006/mvre.1999.2179.
Article
CAS
PubMed
Google Scholar
Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG: Tyrosine 1101 of Tie-2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Molecular and Cell Biology. 1998, 18: 4131-4140.
Article
CAS
Google Scholar
Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ: Identification of Tek/Tie-2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Journal of Biological Chemistry. 1999, 274: 30896-30905. 10.1074/jbc.274.43.30896.
Article
CAS
PubMed
Google Scholar
Kwak HJ, So JN, Lee SJ, Kim I, Koh GY: Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett. 1999, 448 (2–3): 249-253. 10.1016/S0014-5793(99)00378-6.
Article
CAS
PubMed
Google Scholar
Kim I, Kim HG, So JN, Kim JH, Kwak HJ, Koh GY: Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3-Kinase/Akt signal transduction pathway. Circulation Research. 2000, 86: 24-29.
Article
CAS
PubMed
Google Scholar
Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC: Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. Journal of Biological Chemistry. 2000, 275 (13): 9102-9105. 10.1074/jbc.275.13.9102.
Article
CAS
PubMed
Google Scholar
Babaei S, Teichert-Kuliszewska K, Zhang Q, Jones N, Dumont DJ, Stewart DJ: Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide. American Journal of Pathology. 2003, 162 (6): 1927-1936.
Article
PubMed Central
CAS
PubMed
Google Scholar
Murakami T, Takagi H, Suzuma K, Suzuma I, Ohashi H, Watanabe D, Ojima T, Suganami E, Kurimoto M, Kaneto H, Honda Y, Yoshimura N: Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells. Journal of Biological Chemistry. 2005, 280 (36): 31841-31849. 10.1074/jbc.M503108200.
Article
CAS
PubMed
Google Scholar
Zagzag D, Amirnovin R, Greco MA, Yee H, Holash J, Wiegand SJ, Zabski S, Yancopoulos GD, Grumet M: Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis. Lab Invest. 2000, 80: 837-849.
Article
CAS
PubMed
Google Scholar
Cohen B, Barkan D, Levy Y, Goldberg I, Fridman E, Kopolovic J, Rubinstein M: Leptin induces angiopoietin-2 expression in adipose tissues. Journal of Biological Chemistry. 2001, 276: 7697-7700. 10.1074/jbc.C000634200.
Article
CAS
PubMed
Google Scholar
Nag S, Papneja T, Venugopalan R, Stewart DJ: Increased angiopoietin2 expression is associated with endothelial apoptosis and blood-brain barrier breakdown. Laboratory Investigations. 2005, 85 (10): 1189-1198. 10.1038/labinvest.3700325.
Article
CAS
Google Scholar
Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS: Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proceedings of the National Academy of Science USA. 2006, 103 (42): 15491-15496. 10.1073/pnas.0607538103.
Article
CAS
Google Scholar
Ahmad SA, Liu W, Jung YD, Fan F, Wilson M, Reinmuth N, Bucana CD, Ellis LM: Differential expression of angiopoietin-1 and angiopoietin-2 in Colon Carcinoma. Cancer. 2001, 92 (5): 1138-1143. 10.1002/1097-0142(20010901)92:5<1138::AID-CNCR1431>3.0.CO;2-L.
Article
CAS
PubMed
Google Scholar
Ahmad SA, Liu W, Jung YD, Fan F, Wilson M, Reinmuth N, Shaheen RM, Bucana CD, Ellis LM: The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer research. 2001, 61: 1255-1259.
CAS
PubMed
Google Scholar
Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, Kitadai Y, Haruma K, Chayama K: Clinical significance of angiopoietin-2 expression at the deepest invasive tumour site of advanced colorectal carcinoma. International Journal of Oncology. 2004, 24: 539-547.
CAS
PubMed
Google Scholar
Sfiligoi C, de Luca A, Cascone I, Sorbello V, Fuso L, Ponzone R, Biglia N, Audero E, Arisio R, Bussolino F, Sismondi P, De Bortoli M: Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. International Journal of Cancer. 2003, 103 (4): 466-474. 10.1002/ijc.10851.
Article
CAS
Google Scholar
Etoh T, Inoue H, Tanaka S, Barnard GF, Kitano S, Mori M: Angiopietin-2 is related to tumour angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Research. 2001, 61: 2145-2153.
CAS
PubMed
Google Scholar
Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR: Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. The Journal of Clinical Investigation. 1999, 103 (3): 341-345.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, Yoshidome H, Kato A, Nukui Y, Miyazaki M: Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology. 2003, 37 (5): 1105-1113. 10.1053/jhep.2003.50204.
Article
CAS
PubMed
Google Scholar
Takanami I: Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. Oncology Report. 2004, 12 (4): 849-853.
CAS
Google Scholar
Lind AJ, Wikström P, Granfors T, Egevad L, Stattin P, Bergh A: Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer. The Prostate. 2005, 62: 394-399. 10.1002/pros.20163.
Article
PubMed
Google Scholar
Hata K, Nakayama K, Fujiwaki R, Katabuchi H, Okamura H, Miyazaki K: Expression of the angiopoietin-1, angiopoietin-2, Tie-2, and vascular endothelial growth factor gene in epithelial ovarian cancer. Gynecologic Oncology. 2004, 93: 215-222. 10.1016/j.ygyno.2003.12.031.
Article
CAS
PubMed
Google Scholar
Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ, Hawkins N, Rosenfeld R, Davy E, Graham K, Jacobsen F, Stevenson S, Ho J, Chen Q, Hartman T, Michaels M, Kelley M, Li L, Sitney K, Martin F, Sun J-R, Zhang N, Lu J, Estrada J, Kumar R, Coxon A, Kaufman S, Pretorius J, Scully S, Cattley R, Payton M, Coats S, Nguyen L, Desilva B, Ndifor A, Hayward I, Radinsky R, Boone T, Kendall R: Suppression of angiogenesis and tumour growth by selective inhibition of angiopoietin-2. Cancer Cell. 2004, 6: 507-516. 10.1016/j.ccr.2004.09.030.
Article
CAS
PubMed
Google Scholar
Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Research. 1994, 22: 4673-4680. 10.1093/nar/22.22.4673.
Article
PubMed Central
CAS
PubMed
Google Scholar