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  1. The fibre type attributes and the relationships among their properties play an important role in the differences in muscle capabilities and features. Comprehensive characterisation of the skeletal muscles shou...

    Authors: Natalia Moreno-Sánchez, Clara Díaz, María J Carabaño, Julia Rueda and José-Luis L Rivero
    Citation: BMC Cell Biology 2008 9:67
    Content type: Research article Published on:

  2. Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase ki...

    Authors: Gyung-Ah Jung, Ju-Yong Yoon, Byoung-San Moon, Dong-Hwa Yang, Hyun-Yi Kim, Sang-Hun Lee, Vitezslav Bryja, Ernest Arenas and Kang-Yell Choi
    Citation: BMC Cell Biology 2008 9:66
    Content type: Research article Published on:

  3. Cells use filopodia to explore their environment and to form new adhesion contacts for motility and spreading. The Arp2/3 complex has been implicated in lamellipodial actin assembly as a major nucleator of new...

    Authors: Simon A Johnston, Jonathan P Bramble, Chun L Yeung, Paula M Mendes and Laura M Machesky
    Citation: BMC Cell Biology 2008 9:65
    Content type: Research article Published on:

  4. Molecular spacing is important for cell adhesion in a number of ways, ranging from the ordered arrangement of matrix polymers extracellularly, to steric hindrance of adhesion/signaling complexes intracellularl...

    Authors: Tobias Wolfram, Joachim P Spatz and Robert W Burgess
    Citation: BMC Cell Biology 2008 9:64
    Content type: Research article Published on:

  5. The apical junctional complex (AJC) is a dynamic structure responsible to maintain epithelial cell-cell adhesions and it plays important functions such as, polarity, mechanical integrity, and cell signaling. A...

    Authors: Marcelo N Tanaka, Bruno L Diaz, Wanderley de Souza and Jose A Morgado-Diaz
    Citation: BMC Cell Biology 2008 9:63
    Content type: Research article Published on:

  7. Roundabouts are axon guidance molecules that have recently been identified to play a role in vascular guidance as well. In this study, we have investigated gene knockdown analysis of endothelial Robos, in part...

    Authors: Sukhbir Kaur, Ganesh V Samant, Kallal Pramanik, Philip W Loscombe, Michael L Pendrak, David D Roberts and Ramani Ramchandran
    Citation: BMC Cell Biology 2008 9:61
    Content type: Research article Published on:

  8. Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely researched adult stem cell population capable of differentiation into various lineages. Because many promising applications of tissue engineering...

    Authors: James D Kretlow, Yu-Qing Jin, Wei Liu, Wen Jie Zhang, Tan-Hui Hong, Guangdong Zhou, L Scott Baggett, Antonios G Mikos and Yilin Cao
    Citation: BMC Cell Biology 2008 9:60
    Content type: Research article Published on:

  9. Aggresomes are juxtanuclear inclusion bodies that have been proposed to represent a general cellular response to misfolded proteins in mammalian cells. Yet, why aggresomes are not a pathological characteristic...

    Authors: Simon Beaudoin, Kevin Goggin, Cyntia Bissonnette, Catherine Grenier and Xavier Roucou
    Citation: BMC Cell Biology 2008 9:59
    Content type: Research article Published on:

  10. The mechanisms and components that regulate macropinocytosis are poorly understood. Here we have investigated the role of sorting nexin 5 (SNX5) in the regulation of macropinocytic activity.

    Authors: Jet Phey Lim, Jack TH Wang, Markus C Kerr, Rohan D Teasdale and Paul A Gleeson
    Citation: BMC Cell Biology 2008 9:58
    Content type: Research article Published on:

  11. The organic solute transporter (OSTα-OSTβ) is a heteromeric transporter that is expressed on the basolateral membrane of epithelium in intestine, kidney, liver, testis and adrenal gland and facilitates efflux ...

    Authors: Carol J Soroka, Shuhua Xu, Albert Mennone, Ping Lam and James L Boyer
    Citation: BMC Cell Biology 2008 9:57
    Content type: Research article Published on:

  12. Chimeric proteins obtained by the fusion of a G protein-coupled receptor (GPCR) sequence to the N-terminus of the G protein α-subunit have been extensively used to investigate several aspects of GPCR signallin...

    Authors: Maria Grazia Di Certo, Enrico M Batassa, Ida Casella, Annalucia Serafino, Aristide Floridi, Claudio Passananti, Paola Molinari and Elisabetta Mattei
    Citation: BMC Cell Biology 2008 9:56
    Content type: Research article Published on:

  13. In Saccharomyces cerevisiae, nutrient limitation stimulates diploid cells to undergo DNA replication and meiosis, followed by the formation of four haploid spores. Septins are a family of proteins that assemble a...

    Authors: M Evangelina Pablo-Hernando, Yolanda Arnaiz-Pita, Hiroyuki Tachikawa, Francisco del Rey, Aaron M Neiman and Carlos R Vázquez de Aldana
    Citation: BMC Cell Biology 2008 9:55
    Content type: Research article Published on:

  14. Carnation Italian ringspot virus (CIRV) is a positive-strand RNA virus that causes massive structural alterations of mitochondria in infected host cells, the most conspicuous being the formation of numerous inter...

    Authors: Yeen Ting Hwang, Andrew W McCartney, Satinder K Gidda and Robert T Mullen
    Citation: BMC Cell Biology 2008 9:54
    Content type: Research article Published on:

  15. The direction of cytokine secretion from polarized cells determines the cytokine's cellular targets. Leukemia inhibitory factor (LIF) belongs to the interleukin-6 (IL-6) family of cytokines and signals through...

    Authors: Eric J Hill and Ann B Vernallis
    Citation: BMC Cell Biology 2008 9:53
    Content type: Research article Published on:

  16. Human mesenchymal stromal cells (MSCs, also known as mesenchymal stem cells) are multipotent cells with potential therapeutic value. Owing to their osteogenic capability, MSCs may be clinically applied for fac...

    Authors: Irene Fung Ying Mo, Kevin Hak Kong Yip, Wing Keung Chan, Helen Ka Wai Law, Yu Lung Lau and Godfrey Chi Fung Chan
    Citation: BMC Cell Biology 2008 9:52
    Content type: Research article Published on:

  17. IkappaB kinases (IKKs) regulate the activity of Rel/NF-kappaB transcription factors by targeting their inhibitory partner proteins, IkappaBs, for degradation. The Drosophila genome encodes two members of the IKK ...

    Authors: Dikla Dubin-Bar, Amir Bitan, Anna Bakhrat, Rotem Kaiden-Hasson, Sharon Etzion, Boaz Shaanan and Uri Abdu
    Citation: BMC Cell Biology 2008 9:51
    Content type: Research article Published on:

  19. Hedgehog (Hh) signaling is a conserved morphogenetic pathway which plays critical roles in embryonic development, with emerging evidence also supporting a role in healing and repair processes and tumorigenesis...

    Authors: Robert J Lipinski, Maarten F Bijlsma, Jerry J Gipp, David J Podhaizer and Wade Bushman
    Citation: BMC Cell Biology 2008 9:49
    Content type: Research article Published on:

  20. Focal Adhesion Kinase (FAK) is recently reported to regulate insulin resistance by regulating glucose uptake in C2C12 skeletal muscle cells. However, the underlying mechanism for FAK-mediated glucose transport...

    Authors: Bharti Bisht and Chinmoy S Dey
    Citation: BMC Cell Biology 2008 9:48
    Content type: Research article Published on:

  21. Formation of haemorrhagic neovessels in the intima of developing atherosclerotic plaques is thought to significantly contribute to plaque instability resulting in thrombosis. C-reactive protein (CRP) is an acu...

    Authors: Marta M Turu, Mark Slevin, Sabine Matou, David West, Cristina Rodríguez, Ana Luque, Marta Grau-Olivares, Lina Badimon, Jose Martinez-Gonzalez and Jerzy Krupinski
    Citation: BMC Cell Biology 2008 9:47
    Content type: Research article Published on:

  22. The normal growth and function of mammary epithelial cells depend on interactions with the supportive stroma. Alterations in this communication can lead to the progression or expansion of malignant growth. The...

    Authors: JM Fleming, EL Long, E Ginsburg, D Gerscovich, PS Meltzer and BK Vonderhaar
    Citation: BMC Cell Biology 2008 9:46
    Content type: Research article Published on:

  23. Mechanisms of long chain fatty acid uptake across the plasma membrane are important targets in treatment of many human diseases like obesity or hepatic steatosis. Long chain fatty acid translocation is achieve...

    Authors: Robert Ehehalt, Richard Sparla, Hasan Kulaksiz, Thomas Herrmann, Joachim Füllekrug and Wolfgang Stremmel
    Citation: BMC Cell Biology 2008 9:45
    Content type: Research article Published on:

  24. Myosin-Vb has been shown to be involved in the recycling of diverse proteins in multiple cell types. Studies on transferrin trafficking in HeLa cells using a dominant-negative myosin-Vb tail fragment suggested...

    Authors: D William Provance Jr, Erin J Addison, Patrick R Wood, David Z Chen, Colleen M Silan and John A Mercer
    Citation: BMC Cell Biology 2008 9:44
    Content type: Research article Published on:

  25. High Content Screening has been shown to improve results of RNAi and other perturbations, however significant intra-sample heterogeneity is common and can complicate some analyses. Single cell cytometry can ex...

    Authors: Peter LaPan, Jing Zhang, Jing Pan, Andrew Hill and Steven A Haney
    Citation: BMC Cell Biology 2008 9:43
    Content type: Methodology article Published on:

  27. Aromatase, the cytochrome P-450 enzyme (CYP19) responsible for estrogen biosynthesis, is an important target for the treatment of estrogen-dependent breast cancer. In fact, the use of synthetic aromatase inhib...

    Authors: Margarida Cepa, Georgina Correia-da-Silva, Elisiário J Tavares da Silva, Fernanda MF Roleira, Margarida Borges and Natércia A Teixeira
    Citation: BMC Cell Biology 2008 9:41
    Content type: Research article Published on:

  28. In this study, we have investigated the viscoelastic behaviour of individual human adult bone marrow-derived mesenchymal stem cells (hMSCs) and the role of F-actin filaments in maintaining these properties, us...

    Authors: Samuel CW Tan, Wen X Pan, Gang Ma, Ning Cai, Kam W Leong and Kin Liao
    Citation: BMC Cell Biology 2008 9:40
    Content type: Research article Published on:

  29. The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlle...

    Authors: Sandra S Haenni, Matthias Altmeyer, Paul O Hassa, Taras Valovka, Monika Fey and Michael O Hottiger
    Citation: BMC Cell Biology 2008 9:39
    Content type: Research article Published on:

  30. A complex of three cell adhesion molecules (CAMs) Neurexin IV(Nrx IV), Contactin (Cont) and Neuroglian (Nrg) is implicated in the formation of septate junctions between epithelial cells in Drosophila. These CAMs ...

    Authors: Monique Laval, Christophe Bel and Catherine Faivre-Sarrailh
    Citation: BMC Cell Biology 2008 9:38
    Content type: Research article Published on:

  31. FUS, EWS and TAF15 are structurally similar multifunctional proteins that were first discovered upon characterization of fusion oncogenes in human sarcomas and leukemias. The proteins belong to the FET (previo...

    Authors: Mattias K Andersson, Anders Ståhlberg, Yvonne Arvidsson, Anita Olofsson, Henrik Semb, Göran Stenman, Ola Nilsson and Pierre Åman
    Citation: BMC Cell Biology 2008 9:37
    Content type: Research article Published on:

  33. There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to de...

    Authors: Per Lönnbro, Pontus Nordenfelt and Hans Tapper
    Citation: BMC Cell Biology 2008 9:35
    Content type: Methodology article Published on:

  34. Lamellar bodies are lysosome-related secretory granules and store lung surfactant in alveolar type II cells. To better understand the mechanisms of surfactant secretion, we carried out proteomic analyses of la...

    Authors: Pengcheng Wang, Narendranath Reddy Chintagari, Jeyaparthasarathy Narayanaperumal, Sahlu Ayalew, Steven Hartson and Lin Liu
    Citation: BMC Cell Biology 2008 9:34
    Content type: Research article Published on:

  35. Sulphur mustard gas, 2, 2'-dichlorodiethyl sulphide (HD), is a chemical warfare agent. Both mustard gas and its monofunctional analogue, 2-chloroethyl ethyl sulphide (CEES), are alkylating agents that react wi...

    Authors: Victor Paromov, Min Qui, Hongsong Yang, Milton Smith and William L Stone
    Citation: BMC Cell Biology 2008 9:33
    Content type: Research article Published on:

  36. Inside the cell, the HIV Tat protein is mainly found in the nucleus and nucleolus. The nucleolus, the site of ribosome biogenesis, is a highly organized, non-membrane-bound sub-compartment where proteins with ...

    Authors: Donatella Ponti, Maria Troiano, Gian Carlo Bellenchi, Piero A Battaglia and Franca Gigliani
    Citation: BMC Cell Biology 2008 9:32
    Content type: Research article Published on:

  37. Fas and FasL is important mediators of apoptosis. We have previously reported that the stress levels of corticosterone (CORT, glucocorticoid in rat) increase expression of Fas/FasL and activate Fas/FasL signal...

    Authors: Wei-Ran Chai, Yong Chen, Qian Wang and Hui-Bao Gao
    Citation: BMC Cell Biology 2008 9:31
    Content type: Research article Published on:

  38. Cholesterol-rich membrane microdomains known as lipid rafts have been implicated in diverse physiologic processes including lipid transport and signal transduction. Lipid rafts were originally defined as deter...

    Authors: Rosalyn M Adam, Wei Yang, Dolores Di Vizio, Nishit K Mukhopadhyay and Hanno Steen
    Citation: BMC Cell Biology 2008 9:30
    Content type: Methodology article Published on:

  40. The V-ATPase (VHA) is a protein complex of 13 different VHA-subunits. It functions as an ATP driven rotary-motor that electrogenically translocates H+ into endomembrane compartments. In Arabidopsis thaliana V-ATP...

    Authors: Thorsten Seidel, Daniel Schnitzer, Dortje Golldack, Markus Sauer and Karl-Josef Dietz
    Citation: BMC Cell Biology 2008 9:28
    Content type: Research article Published on:

  41. The tissue distributions and functions of Eph receptors and their ephrin ligands have been well studied, however less is known about their evolutionary history. We have undertaken a phylogenetic analysis of Ep...

    Authors: Dan O Mellott and Robert D Burke
    Citation: BMC Cell Biology 2008 9:27
    Content type: Research article Published on:

  43. Insulin stimulates glucose uptake by adipocytes through increasing translocation of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane. Fusion of GLUT4-containing vesicles a...

    Authors: Catherine A Heyward, Trevor R Pettitt, Sophie E Leney, Gavin I Welsh, Jeremy M Tavaré and Michael JO Wakelam
    Citation: BMC Cell Biology 2008 9:25
    Content type: Research article Published on:

  44. Human mesenchymal stem cells (MSCs) have been studied and applied extensively because of their ability to self-renew and differentiate into various cell types. Since most human diseases models are murine, mous...

    Authors: Yong Li, Cheng Zhang, Fu Xiong, Mei-juan Yu, Fu-lin Peng, Yan-chang Shang, Cui-ping Zhao, Yong-feng Xu, Zheng-shan Liu, Chang Zhou and Jin-lang Wu
    Citation: BMC Cell Biology 2008 9:24
    Content type: Research article Published on:

  45. The fission yeast Schizosaccharomyces pombe is widely-used as a model organism for the study of a broad range of eukaryotic cellular processes such as cell cycle, genome stability and cell morphology. Despite the...

    Authors: Cathrine A Bøe, Ignacio Garcia, Chen-Chun Pai, Jeffrey R Sharom, Henriette C Skjølberg, Erik Boye, Stephen Kearsey, Stuart A MacNeill, Michael D Tyers and Beáta Grallert
    Citation: BMC Cell Biology 2008 9:23
    Content type: Methodology article Published on:

  46. Two nuclear localization sequences (NLS) in influenza A virus nucleoprotein (NP) have been demonstrated to be critical for nuclear import of NP and viral ribonucleoprotein complexes. However, a deletion mutant...

    Authors: Krishna Mohan V Ketha and Chintamani D Atreya
    Citation: BMC Cell Biology 2008 9:22
    Content type: Research article Published on:

  47. Kinesin and dynein are the two families of microtubule-based motors that drive much of the intracellular movements in eukaryotic cells. Using a gene knockout strategy, we address here the individual function(s...

    Authors: Dilip K Nag, Irina Tikhonenko, Ikko Soga and Michael P Koonce
    Citation: BMC Cell Biology 2008 9:21
    Content type: Research article Published on:

  48. Chimpanzee dental pulp stem/stromal cells (ChDPSCs) are very similar to human bone marrow derived mesenchymal stem/stromal cells (hBMSCs) as demonstrated by the expression pattern of cell surface markers and t...

    Authors: Pei-Hsun Cheng, Brooke Snyder, Dimitri Fillos, Chris C Ibegbu, Anderson Hsien-Cheng Huang and Anthony WS Chan
    Citation: BMC Cell Biology 2008 9:20
    Content type: Research article Published on:

  49. Neutrophils leave the bone marrow as terminally differentiated cells, yet little is known of the influence of nicotine or other tobacco smoke components on neutrophil differentiation. Therefore, promyelocytic ...

    Authors: Minqi Xu, James E Scott, Kan-Zhi Liu, Hannah R Bishop, Diane E Renaud, Richard M Palmer, Abdel Soussi-Gounni and David A Scott
    Citation: BMC Cell Biology 2008 9:19
    Content type: Research article Published on:

  50. Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand (hypoxia). Cells within hypoxic regions respond with the induction...

    Authors: Maria L Alcaide-German, Alicia Vara-Vega, Luis F Garcia-Fernandez, Manuel O Landazuri and Luis del Peso
    Citation: BMC Cell Biology 2008 9:18
    Content type: Research article Published on:
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