Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972, 26 (4): 239-257.
PubMed Central
CAS
PubMed
Google Scholar
Steller H: Mechanisms and genes of cellular suicide. Science. 1995, 267 (5203): 1445-1449. 10.1126/science.7878463.
CAS
PubMed
Google Scholar
Nezis IP, Stravopodis DJ, Papassideri I, Robert-Nicoud M, Margaritis LH: Stage-specific apoptotic patterns during Drosophila oogenesis. Eur J Cell Biol. 2000, 79 (9): 610-620. 10.1078/0171-9335-00088.
CAS
PubMed
Google Scholar
Levine B, Klionsky DJ: Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004, 6 (4): 463-477. 10.1016/S1534-5807(04)00099-1.
CAS
PubMed
Google Scholar
Nicholson DW: Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 1999, 6 (11): 1028-1042. 10.1038/sj.cdd.4400598.
CAS
PubMed
Google Scholar
Hengartner MO: The biochemistry of apoptosis. Nature. 2000, 407 (6805): 770-776. 10.1038/35037710.
CAS
PubMed
Google Scholar
Thornberry NA: The caspase family of cysteine proteases. Br Med Bull. 1997, 53 (3): 478-490.
CAS
PubMed
Google Scholar
Kumar S, Doumanis J: The fly caspases. Cell Death Differ. 2000, 7 (11): 1039-1044. 10.1038/sj.cdd.4400756.
CAS
PubMed
Google Scholar
Vernooy SY, Copeland J, Ghaboosi N, Griffin EE, Yoo SJ, Hay BA: Cell death regulation in Drosophila: conservation of mechanism and unique insights. J Cell Biol. 2000, 150 (2): F69-76. 10.1083/jcb.150.2.F69.
CAS
PubMed
Google Scholar
Hay BA, Guo M: Caspase-dependent cell death in Drosophila. Annu Rev Cell Dev Biol. 2006, 22: 623-650. 10.1146/annurev.cellbio.21.012804.093845.
CAS
PubMed
Google Scholar
Abrams JM: An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 1999, 9 (11): 435-440. 10.1016/S0962-8924(99)01646-3.
CAS
PubMed
Google Scholar
Song Q, Lu H, Zhang N, Luckow B, Shah G, Poirier G, Lavin M: Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease. Biochem Biophys Res Commun. 1997, 233 (2): 343-348. 10.1006/bbrc.1997.6456.
CAS
PubMed
Google Scholar
Song Z, McCall K, Steller H: DCP-1, a Drosophila cell death protease essential for development. Science. 1997, 275 (5299): 536-540. 10.1126/science.275.5299.536.
CAS
PubMed
Google Scholar
Kuranaga E, Miura M: Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol. 2007, 17 (3): 135-144. 10.1016/j.tcb.2007.01.001.
CAS
PubMed
Google Scholar
Kondo S, Senoo-Matsuda N, Hiromi Y, Miura M: DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol. 2006, 26 (19): 7258-7268. 10.1128/MCB.00183-06.
PubMed Central
CAS
PubMed
Google Scholar
Huh JR, Vernooy SY, Yu H, Yan N, Shi Y, Guo M, Hay BA: Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2004, 2 (1): E15-10.1371/journal.pbio.0020015.
PubMed Central
PubMed
Google Scholar
McCall K, Steller H: Requirement for DCP-1 caspase during Drosophila oogenesis. Science. 1998, 279 (5348): 230-234. 10.1126/science.279.5348.230.
CAS
PubMed
Google Scholar
Laundrie B, Peterson JS, Baum JS, Chang JC, Fileppo D, Thompson SR, McCall K: Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics. 2003, 165 (4): 1881-1888.
PubMed Central
CAS
PubMed
Google Scholar
Giorgi F, Deri P: Cell death in ovarian chambers of Drosophila melanogaster. J Embryol Exp Morphol. 1976, 35 (3): 521-533.
CAS
PubMed
Google Scholar
Chao S, Nagoshi RN: Induction of apoptosis in the germline and follicle layer of Drosophila egg chambers. Mech Dev. 1999, 88 (2): 159-172. 10.1016/S0925-4773(99)00183-5.
CAS
PubMed
Google Scholar
Drummond-Barbosa D, Spradling AC: Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev Biol. 2001, 231 (1): 265-278. 10.1006/dbio.2000.0135.
CAS
PubMed
Google Scholar
Song Z, Guan B, Bergman A, Nicholson DW, Thornberry NA, Peterson EP, Steller H: Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. Mol Cell Biol. 2000, 20 (8): 2907-2914. 10.1128/MCB.20.8.2907-2914.2000.
PubMed Central
CAS
PubMed
Google Scholar
Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B: The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 2000, 1 (4): 353-358. 10.1093/embo-reports/kvd073.
PubMed Central
CAS
PubMed
Google Scholar
Cadavid AL, Ginzel A, Fischer JA: The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development. 2000, 127 (8): 1727-1736.
CAS
PubMed
Google Scholar
Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H: Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol. 2002, 4 (6): 432-438. 10.1038/ncb795.
CAS
PubMed
Google Scholar
Juhasz G, Csikos G, Sinka R, Erdelyi M, Sass M: The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Lett. 2003, 543 (1-3): 154-158. 10.1016/S0014-5793(03)00431-9.
CAS
PubMed
Google Scholar
Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M: A ubiquitin-like system mediates protein lipidation. Nature. 2000, 408 (6811): 488-492. 10.1038/35044114.
CAS
PubMed
Google Scholar
Lippai M, Csikos G, Maroy P, Lukacsovich T, Juhasz G, Sass M: SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy. Autophagy. 2008, 4 (4): 476-486.
CAS
PubMed
Google Scholar
Finley KD, Edeen PT, Cumming RC, Mardahl-Dumesnil MD, Taylor BJ, Rodriguez MH, Hwang CE, Benedetti M, McKeown M: blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J Neurosci. 2003, 23 (4): 1254-1264.
PubMed Central
CAS
PubMed
Google Scholar
Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H: Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci. 2004, 117 (Pt 18): 4239-4251. 10.1242/jcs.01287.
CAS
PubMed
Google Scholar
Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics. 2007, 176 (2): 1283-1297. 10.1534/genetics.106.065011.
PubMed Central
CAS
PubMed
Google Scholar
Maiuri MC, Zalckvar E, Kimchi A, Kroemer G: Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007, 8 (9): 741-752. 10.1038/nrm2239.
CAS
PubMed
Google Scholar
Kourtis N, Tavernarakis N: Autophagy and cell death in model organisms. Cell Death Differ. 2009, 16 (1): 21-30. 10.1038/cdd.2008.120.
CAS
PubMed
Google Scholar
White E: Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy. 2008, 4 (4): 399-401.
PubMed Central
CAS
PubMed
Google Scholar
Leevers SJ, Vanhaesebroeck B, Waterfield MD: Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol. 1999, 11 (2): 219-225. 10.1016/S0955-0674(99)80029-5.
CAS
PubMed
Google Scholar
Raught B, Gingras AC, Sonenberg N: The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA. 2001, 98 (13): 7037-7044. 10.1073/pnas.121145898.
PubMed Central
CAS
PubMed
Google Scholar
Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell. 2006, 124 (3): 471-484. 10.1016/j.cell.2006.01.016.
CAS
PubMed
Google Scholar
Chung J, Kuo CJ, Crabtree GR, Blenis J: Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. 1992, 69 (7): 1227-1236. 10.1016/0092-8674(92)90643-Q.
CAS
PubMed
Google Scholar
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y: Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol. 2000, 150 (6): 1507-1513. 10.1083/jcb.150.6.1507.
PubMed Central
CAS
PubMed
Google Scholar
Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE: Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science. 1992, 257 (5072): 973-977. 10.1126/science.1380182.
CAS
PubMed
Google Scholar
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP: Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 2000, 14 (21): 2712-2724. 10.1101/gad.835000.
PubMed Central
CAS
PubMed
Google Scholar
Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D: Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol. 2002, 4 (9): 699-704. 10.1038/ncb847.
CAS
PubMed
Google Scholar
Wu Q, Zhang Y, Xu J, Shen P: Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc Natl Acad Sci USA. 2005, 102 (37): 13289-13294. 10.1073/pnas.0501914102.
PubMed Central
CAS
PubMed
Google Scholar
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004, 14 (10): 885-890. 10.1016/j.cub.2004.03.059.
PubMed Central
CAS
PubMed
Google Scholar
Scott RC, Schuldiner O, Neufeld TP: Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell. 2004, 7 (2): 167-178. 10.1016/j.devcel.2004.07.009.
CAS
PubMed
Google Scholar
Huang H, Potter CJ, Tao W, Li DM, Brogiolo W, Hafen E, Sun H, Xu T: PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development. 1999, 126 (23): 5365-5372.
CAS
PubMed
Google Scholar
Lee CY, Baehrecke EH: Steroid regulation of autophagic programmed cell death during development. Development. 2001, 128 (8): 1443-1455.
CAS
PubMed
Google Scholar
Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J: A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007, 179 (4): 619-626. 10.1083/jcb.200708090.
PubMed Central
CAS
PubMed
Google Scholar
Hou YC, Chittaranjan S, Barbosa SG, McCall K, Gorski SM: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J Cell Biol. 2008, 182 (6): 1127-1139. 10.1083/jcb.200712091.
PubMed Central
CAS
PubMed
Google Scholar
Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, Varhol RJ, Coughlin SM, Zuyderduyn SD, Jones SJ, Marra MA: A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol. 2003, 13 (4): 358-363. 10.1016/S0960-9822(03)00082-4.
CAS
PubMed
Google Scholar
Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH: Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr Biol. 2003, 13 (4): 350-357. 10.1016/S0960-9822(03)00085-X.
CAS
PubMed
Google Scholar
Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T, Simon HU: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 2006, 8 (10): 1124-1132. 10.1038/ncb1482.
CAS
PubMed
Google Scholar
Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH: Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem. 2005, 280 (21): 20722-20729. 10.1074/jbc.M413934200.
CAS
PubMed
Google Scholar
Yang C, Kaushal V, Shah SV, Kaushal GP: Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol. 2008, 294 (4): F777-787. 10.1152/ajprenal.00590.2007.
CAS
PubMed
Google Scholar
Abraham MC, Shaham S: Death without caspases, caspases without death. Trends Cell Biol. 2004, 14 (4): 184-193. 10.1016/j.tcb.2004.03.002.
CAS
PubMed
Google Scholar
Baehrecke EH: Autophagic programmed cell death in Drosophila. Cell Death Differ. 2003, 10 (9): 940-945. 10.1038/sj.cdd.4401280.
CAS
PubMed
Google Scholar
Thummel CS: Steroid-triggered death by autophagy. Bioessays. 2001, 23 (8): 677-682. 10.1002/bies.1096.
CAS
PubMed
Google Scholar
Lee CY, Cooksey BA, Baehrecke EH: Steroid regulation of midgut cell death during Drosophila development. Dev Biol. 2002, 250 (1): 101-111. 10.1006/dbio.2002.0784.
CAS
PubMed
Google Scholar
Bergmann A, Agapite J, McCall K, Steller H: The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell. 1998, 95 (3): 331-341. 10.1016/S0092-8674(00)81765-1.
CAS
PubMed
Google Scholar
Juhasz G, Sass M: Hid can induce, but is not required for autophagy in polyploid larval Drosophila tissues. Eur J Cell Biol. 2005, 84 (4): 491-502. 10.1016/j.ejcb.2004.11.010.
CAS
PubMed
Google Scholar
Wang SL, Hawkins CJ, Yoo SJ, Muller HA, Hay BA: The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell. 1999, 98 (4): 453-463. 10.1016/S0092-8674(00)81974-1.
CAS
PubMed
Google Scholar
Lee JH, Koh H, Kim M, Park J, Lee SY, Lee S, Chung J: JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ. 2006, 13 (7): 1110-1122. 10.1038/sj.cdd.4401790.
CAS
PubMed
Google Scholar
Lee SB, Park J, Jung JU, Chung J: Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila. J Cell Sci. 2005, 118 (Pt 9): 1851-1859. 10.1242/jcs.02312.
CAS
PubMed
Google Scholar
Wu H, Wang MC, Bohmann D: JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev. 2009, 126 (8-9): 624-637. 10.1016/j.mod.2009.06.1082.
PubMed Central
CAS
PubMed
Google Scholar
Wang T, Lao U, Edgar BA: TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J Cell Biol. 2009, 186 (5): 703-711. 10.1083/jcb.200904090.
PubMed Central
CAS
PubMed
Google Scholar
Blommaart EF, Luiken JJ, Meijer AJ: Autophagic proteolysis: control and specificity. Histochem J. 1997, 29 (5): 365-385. 10.1023/A:1026486801018.
CAS
PubMed
Google Scholar
Elmore SP, Qian T, Grissom SF, Lemasters JJ: The mitochondrial permeability transition initiates autophagy in rat hepatocytes. Faseb J. 2001, 15 (12): 2286-2287.
CAS
PubMed
Google Scholar
Scott RC, Juhasz G, Neufeld TP: Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007, 17 (1): 1-11. 10.1016/j.cub.2006.10.053.
PubMed Central
CAS
PubMed
Google Scholar
Han K: An efficient DDAB-mediated transfection of Drosophila S2 cells. Nucleic Acids Res. 1996, 24 (21): 4362-4363. 10.1093/nar/24.21.4362.
PubMed Central
CAS
PubMed
Google Scholar
Kim YI, Cho JH, Yoo OJ, Ahnn J: Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C. J Mol Biol. 2004, 342 (2): 421-433. 10.1016/j.jmb.2004.07.036.
CAS
PubMed
Google Scholar