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404 result(s) for 'apoptosis' within BMC Molecular and Cell Biology

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  1. Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor ... and/or activation by human Fas ligand induces apoptosis and caspase activities, in cultur...

    Authors: Gerasimos Filippatos, Edmund Ang, Claudia Gidea, Erhan Dincer, Rongqi Wang and Bruce D Uhal
    Citation: BMC Cell Biology 2004 5:6
  2. The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.

    Authors: Jun-qi Guo, Xia Gao, Zhi-jie Lin, Wei-zhen Wu, Liang-hu Huang, Hui-yue Dong, Jin Chen, Jun Lu, Yun-fen Fu, Jin Wang, Yu-jie Ma, Xiao-wen Chen, Zhi-xian Wu, Fu-qiang He, Shun-liang Yang, Lian-ming Liao…
    Citation: BMC Cell Biology 2013 14:18
  3. Eosinophilic granulocytes are important for the human immune system. Many cationic proteins with cytotoxic activities, such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), are releas...

    Authors: Kun-Che Chang, Chih-Wei Lo, Tan-chi Fan, Margaret Dah-Tsyr Chang, Chih-Wen Shu, Chuan-Hsin Chang, Cheng-Ta Chung, Shun-lung Fang, Chih-Chung Chao, Jaw-Ji Tsai and Yiu-Kay Lai
    Citation: BMC Cell Biology 2010 11:6
  4. The goal of this study was to investigate the anti-angiogenic activity of a novel peptide H-RN, derived from the hepatocyte growth factor kringle 1 domain (HGF K1), in a mouse model of corneal neovascularizati...

    Authors: Ye Sun, Li Su, Zhongxiao Wang, Yi Xu and Xun Xu
    Citation: BMC Cell Biology 2013 14:8
  5. Here, we report for the first time that RLX has anti-cancer property against panel of human cancer cell lines and most potent activity was found against HCT-116 cells with IC50...value of 12 Î¼M and have further i...

    Authors: Asif Khurshid Qazi, Aashiq Hussain, Mushtaq A Aga, Shakir Ali, Subhash Chandra Taneja, Parduman Raj Sharma, Ajit Kumar Saxena, Dilip M Mondhe and Abid Hamid
    Citation: BMC Cell Biology 2014 15:36
  6. Interferon-α (IFN-α) exerts an anti-tumor effect at least through induction of apoptosis in a variety of types including B...2...-terminal kinase1 (JNK1), which is implicated in activation of the tumor necrosis f...

    Authors: Noriko Yanase, Miho Hayashida, Yuki Kanetaka-Naka, Akinori Hoshika and Junichiro Mizuguchi
    Citation: BMC Cell Biology 2012 13:7
  7. In comparison with non-treated cells, we found that the ATX-LPA axis up-regulated OPN expression by 1.92-fold in protein levels and 1.3-fold in mRNA levels. The ATX-LPA axis activates LPA2, Akt, ERK and ELK-1 and...

    Authors: Rihua Zhang, Jing Wang, Shijie Ma, Zuhu Huang and Guoxin Zhang
    Citation: BMC Cell Biology 2011 12:11
  8. Bcl-2 homology domain (BH) 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to the mitochondrial cell death pathways. The BH3-only protein Bid can be activated in response...

    Authors: Hans-Georg König, Markus Rehm, Daniel Gudorf, Stan Krajewski, Atan Gross, Manus W Ward and Jochen HM Prehn
    Citation: BMC Cell Biology 2007 8:7
  9. The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively hi...

    Authors: Zhihong Chen, Yinlin Ge and Jing X Kang
    Citation: BMC Cell Biology 2004 5:15
  10. In several species with external fertilization, including frogs, laid unfertilized eggs were found to die by apoptosis outside of the animal body. However, ... to degrade by this process, considering that apoptosis

    Authors: Sho Iguchi, Tetsushi Iwasaki, Yasuo Fukami and Alexander A Tokmakov
    Citation: BMC Cell Biology 2013 14:11
  11. Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajuncti...

    Authors: Neal E Beeman, Heidi K Baumgartner, Patricia G Webb, Jerome B Schaack and Margaret C Neville
    Citation: BMC Cell Biology 2009 10:85
  12. After discussing some characteristics of the methods employed and their limitations, a succession of apoptotic events over time is suggested, in which the collapse of mitochondrial transmembrane potential (Δψm) i...

    Authors: Francesco Fabbri, Silvia Carloni, Giovanni Brigliadori, Wainer Zoli, Rosa Lapalombella and Marina Marini
    Citation: BMC Cell Biology 2006 7:6
  13. Retinoid-inducible gene 1 (RIG1), also known as tazarotene-induced gene 3 or retinoic-acid receptor responder 3, is a growth regulator, which induces apoptosis and differentiation. RIG1 is classified into the ......

    Authors: Fu-Ming Tsai, Rong-Yaun Shyu, Su-Ching Lin, Chang-Chieh Wu and Shun-Yuan Jiang
    Citation: BMC Cell Biology 2009 10:15
  14. High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear.

    Authors: Changhong Tan, Xi Liu, Xiaoshuai Zhang, Wuxue Peng, Hui Wang, Wen Zhou, Jin Jiang, Lijuan Mo, Yangmei Chen and Lifen Chen
    Citation: BMC Molecular and Cell Biology 2021 22:58
  15. To investigate the biological function of HCCR-1 in the cell, we predicted biological features using bioinformatic tools, and have identified a LETM1 homologous domain at position 75 to 346 of HCCR-1. This dom...

    Authors: Goang-Won Cho, Seung Min Shin, Hyun Kee Kim, Seon-Ah Ha, Sanghee Kim, Joo-Hee Yoon, Soo Young Hur, Tae Eung Kim and Jin Woo Kim
    Citation: BMC Cell Biology 2007 8:50
  16. We demonstrated that ARNTL2 upregulation of ACOT7 was critical for NSCLC cell growth and proliferation. Firstly, overexpression of ARNTL2 conferred the poor prognosis of LUAD patients and supported the proliferat...

    Authors: Tao Wang, Kai Wang, Xu Zhu and Nan Chen
    Citation: BMC Molecular and Cell Biology 2023 24:14
  17. The impact of PTX, SFN, and their combination on cell viability reduction was evaluated in a dose-dependent manner. The combined treatment enhanced PTX’s effects and decreased the EC50 values of both drugs compar...

    Authors: Tito N. Habib, Mohammed O. Altonsy, Salah A. Ghanem, Mohamed S. Salama and Mai A. Hosny
    Citation: BMC Molecular and Cell Biology 2024 25:5
  18. The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic β-cells and con...

    Authors: Liling Zhang, Courtney Nosak, Pietro Sollazzo, Tanya Odisho and Allen Volchuk
    Citation: BMC Cell Biology 2014 15:29
  19. The serine/threonine protein kinase B (PKB/Akt) is involved in insulin signaling, cellular survival, and transformation. Carboxyl-terminal modulator protein (CTMP) has been identified as a novel PKB binding partn...

    Authors: Longzhen Piao, Yuwen Li, Keum-Jin Yang, Kyeong Ah Park, Hee Sun Byun, Minho Won, Janghee Hong, Jeong-Lan Kim, Gi Ryang Kweon, Gang Min Hur, Jeong Ho Seok, Jae Youl Cho, Taehoon Chun, Daniel Hess, Ragna Sack, Sauveur-Michel Maira…
    Citation: BMC Cell Biology 2009 10:53
  20. Here, we report that the vast majority of naturally laid unfertilized eggs of the African clawed frog Xenopus laevis spontaneously exit metaphase arrest under various environmental conditions and degrade by a wel...

    Authors: Alexander A Tokmakov, Sho Iguchi, Tetsushi Iwasaki and Yasuo Fukami
    Citation: BMC Cell Biology 2011 12:56
  21. Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play important ...

    Authors: Zhe Peng, Chunli Zhao, Zijing Yang, Shusheng Gong and Zhengde Du
    Citation: BMC Molecular and Cell Biology 2023 24:27
  22. H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppr...

    Authors: Li-Li Yu, Kai Chang, Lin-Shan Lu, Dan Zhao, Jian Han, Ying-Ru Zheng, Yao-Hua Yan, Ping Yi, Jian-Xin Guo, Yuan-Guo Zhou, Ming Chen and Li Li
    Citation: BMC Cell Biology 2013 14:26
  23. It was reported that microRNA-21(miR-21) was differentially expressed in the keratinocytes of psoriasis patients, and it may influence the apoptosis and proliferation of cells. The role of ... MEG3 and miR-21 on ...

    Authors: Hai-Yan Jia, Kai Zhang, Wen-Jing Lu, Gui-Wen Xu, Jian-Fen Zhang and Zhan-Li Tang
    Citation: BMC Molecular and Cell Biology 2019 20:46
  24. TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, can selectively kill cancer cells ... some cancer cells are resistant to TRAIL-induced apoptosis. Thus, reagents that potentiate TRAIL-induced...Lit...

    Authors: Zhi Lan Guo, Jing Zhe Li, Yan Yan Ma, Dan Qian, Ju Ying Zhong, Meng Meng Jin, Peng Huang, Lu Yang Che, Bing Pan, Yi Wang, Zhen Xiao Sun and Chang Zhen Liu
    Citation: BMC Cell Biology 2018 19:29
  25. Our data demonstrate that the expression of miR-423-5p is significantly increased in HG-induced RPE cells and DR patient plasma. Moreover, the overexpression of miR-423-5p exacerbates HG-induced apoptosis. Mechan...

    Authors: Qing Xiao, Yinu Zhao, Jia Xu, Wen-Jie Li, Yu Chen and Hong-Jing Sun
    Citation: BMC Molecular and Cell Biology 2019 20:39
  26. We present evidence that mitochondria are sensitive to the level of cAMP/PKA signaling and can respond by modulating levels of respiratory activity or committing to self execution. The inappropriate activation of...

    Authors: Jane E Leadsham and Campbell W Gourlay
    Citation: BMC Cell Biology 2010 11:92
  27. Endophytes have proven to be an invaluable resource of chemically diverse secondary metabolites that act as excellent lead compounds for anticancer drug discovery. Here we report the promising cytotoxic effect...

    Authors: Mytre Koul, Ashok Kumar, Ramesh Deshidi, Vishal Sharma, Rachna D. Singh, Jasvinder Singh, Parduman Raj Sharma, Bhahwal Ali Shah, Sundeep Jaglan and Shashank Singh
    Citation: BMC Cell Biology 2017 18:26

    The Erratum to this article has been published in BMC Cell Biology 2017 18:27

  28. H/R injury model was established to induce HUVECs to release H/R-EMVs. The H/R-EMVs from HUVECs were isolated from the conditioned culture medium and characterized. H9c2 cardiomyocytes were then incubated with 10...

    Authors: Qi Zhang, Man Shang, Mengxiao Zhang, Yao Wang, Yan Chen, Yanna Wu, Minglin Liu, Junqiu Song and Yanxia Liu
    Citation: BMC Cell Biology 2016 17:25
  29. During apoptosis, Ca2+-dependent events participate in the regulation of intracellular and morphological changes including phosphatidylserine exposure in the exoplasmic leaflet of the cell plasma membrane. The oc...

    Authors: M Carmen Martínez and Jean-Marie Freyssinet
    Citation: BMC Cell Biology 2001 2:20
  30. Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established rol...

    Authors: Anggraini Iriani, Andhika Rachman, Rahayuningsih D. Setiabudy, Siti B. Kresno, Aru W. Sudoyo, Mansyur Arief, Alida R. Harahap and Marsya Kaila Fatina
    Citation: BMC Molecular and Cell Biology 2023 24:33
  31. We now demonstrate that VEGF-induced survival on collagen I impairs the ability of three known angiostatic molecules, TSP-1, IP-10 and endostatin to inhibit endothelial cell proliferation. Apoptosis of endothelia...

    Authors: Christina L Addison, Jacques E Nör, Huijun Zhao, Stephanie A Linn, Peter J Polverini and Christie E Delaney
    Citation: BMC Cell Biology 2005 6:38
  32. Cadmium(Cd), a heavy metal, which has a potent harmful effects, is a highly stress-inducible material that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called ER...

    Authors: Seungwoo Kim, Hyo-Soon Cheon, So-Young Kim, Yong-Sung Juhnn and Young-Youl Kim
    Citation: BMC Cell Biology 2013 14:4
  33. Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass ... . Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-cells. The G protein ... activation can protect...

    Authors: Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath and Baggavalli P Somesh
    Citation: BMC Cell Biology 2014 15:24
  34. The effects of BMP9 on the viability, migration and invasion of HTR-8/Svneo cells were investigated by CCK-8 assay, wound healing assay and Transwell invasion assay. The effect of BMP9 on apoptosis of HTR-8/Svneo...

    Authors: Xue Yang, Lingling Ren, Xiang Chen, Ying Pang, Baoxia Jia, Jing Sun and Xiaofang Quan
    Citation: BMC Molecular and Cell Biology 2023 24:24
  35. Cells respond to endoplasmic reticulum stress (ER) stress by activating the unfolded protein response. To study the ER stress response in pancreatic β-cells we developed a model system that allows for pathophysio...

    Authors: Taila Hartley, Madura Siva, Elida Lai, Tracy Teodoro, Liling Zhang and Allen Volchuk
    Citation: BMC Cell Biology 2010 11:59
  36. INA treatment of various cell lines followed by irradiation with UV light (310–380 nm) resulted in loss of cell viability in a dose dependent manner. The mechanism of cell death appeared to be apoptosis as indica...

    Authors: Mathias Viard, Himanshu Garg, Robert Blumenthal and Yossef Raviv
    Citation: BMC Cell Biology 2009 10:21
  37. We screened ~15,000 EP lines and identified 72 Dcp-1...-interacting genes that were classified into 10 groups based on their functions and pathways: 4 apoptosis signaling genes, 10 autophagy genes, 5 ... screen s...

    Authors: Young-Il Kim, Taewoo Ryu, Judong Lee, Young-Shin Heo, Joohong Ahnn, Seung-Jae Lee and OokJoon Yoo
    Citation: BMC Cell Biology 2010 11:9
  38. Apoptosis is a caspase regulated cell death present ... morphological features. A well-described function of apoptosis is the removal of excessive cells during ... of cell elimination, this new role of apoptosis ...

    Authors: Gabriel Krasovec, Anthi Karaiskou, Éric Quéinnec and Jean-Philippe Chambon
    Citation: BMC Molecular and Cell Biology 2021 22:51
  39. U251 and SHG-44 cells were analyzed in vitro. A CCK-8 assay was performed to verify the effect of TMZ toxicity on GBM cells. Intracellular ROS levels were detected by DCFH-DA assay. A MitoSOX Red assay was per...

    Authors: Hao Chen, Chunlin Li, Haiyang Hu and Bin Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:38
  40. Apoptosis is important for regulating spermatogenesis. The protein ... expressed in the testis and is involved in apoptosis of spermatogonia. GC-1, a spermatogonia...

    Authors: Yong Wang, Wei Song, Shuchun Li, Xin Guan, Shiying Miao, Shudong Zong, SS Koide and Linfang Wang
    Citation: BMC Cell Biology 2009 10:25
  41. Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bunge...

    Authors: Liye Chen, Lili Wei, Qiongyang Yu, Haozhe Shi and George Liu
    Citation: BMC Molecular and Cell Biology 2020 21:20
  42. We validated the decreased expression of MALAT1 in the IDD tissues, which was associated with decreased Collagen II and Aggrecan expression. In vitro,...overexpressed MALAT1 could attenuate the effect of IL-1β on...

    Authors: Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang and Xingguo Li
    Citation: BMC Molecular and Cell Biology 2020 21:23

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