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  1. About 90% of cancer-related deaths are due to metastasis of cancer cells, and angiogenesis is a critical step in this process. sFLT01 is a novel fusion protein and a dual-targeting agent that neutralizes both ...

    Authors: Sepideh Taghizadeh, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Fahimeh Zakeri, Hamid Latifi-Navid and Hoda Shams Najafabadi
    Citation: BMC Molecular and Cell Biology 2021 22:30
  2. Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation t...

    Authors: Elisa Seria, George Galea, Joseph Borg, Kevin Schembri, Gabriella Grech, Sarah Samut Tagliaferro and Alexander Felice
    Citation: BMC Molecular and Cell Biology 2021 22:28
  3. Dinoflagellates have a generally large number of genes but only a small percentage of these are annotated as transcription factors. Cold shock domain (CSD) containing proteins (CSPs) account for roughly 60% of...

    Authors: Bahareh Zaheri and David Morse
    Citation: BMC Molecular and Cell Biology 2021 22:27
  4. Prostate cancer occurs through multiple steps until advanced metastasis. Signaling pathways studies can result in the identification of targets to interrupt cancer progression. Glypicans are cell surface prote...

    Authors: Gabrielle Ferrante Alves de Moraes, Eduardo Listik, Giselle Zenker Justo, Carolina Meloni Vicente and Leny Toma
    Citation: BMC Molecular and Cell Biology 2021 22:26
  5. Capsular fibrosis (CF) is the most common long-term complication in implant-based breast augmentation. It is well accepted that the foreign body response (FBR) instigates the development of fibrotic disease. O...

    Authors: Britta Kuehlmann, Isabel Zucal, Clark Andrew Bonham, Lydia-Marie Joubert and Lukas Prantl
    Citation: BMC Molecular and Cell Biology 2021 22:25
  6. Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglyc...

    Authors: Fangzi Gong, Le Gao, Luyao Ma, Guangxin Li and Jianhong Yang
    Citation: BMC Molecular and Cell Biology 2021 22:24
  7. The SARS-CoV-2 virus, the causative agent of COVID-19, consists of an assembly of proteins that determine its infectious and immunological behavior, as well as its response to therapeutics. Major structural bi...

    Authors: Luciano Kagami, Joel Roca-Martínez, Jose Gavaldá-García, Pathmanaban Ramasamy, K. Anton Feenstra and Wim F. Vranken
    Citation: BMC Molecular and Cell Biology 2021 22:23
  8. Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, S...

    Authors: Zhenghui Cheng, Yawen Zhang, Yinchao Tian, Yuhan Chen, Fei Ding, Han Wu, Yuhua Ji and Mi Shen
    Citation: BMC Molecular and Cell Biology 2021 22:21
  9. Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by bi...

    Authors: Aiyada Aroonsri, Jindaporn Kongsee, Jeremy David Gunawan, Daniel Abidin Aubry and Philip James Shaw
    Citation: BMC Molecular and Cell Biology 2021 22:20
  10. The asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional interactions between human bronchial epithelial cells and human bronchi...

    Authors: Milena Paw, Dawid Wnuk, Bogdan Jakieła, Grażyna Bochenek, Krzysztof Sładek, Zbigniew Madeja and Marta Michalik
    Citation: BMC Molecular and Cell Biology 2021 22:19
  11. Reef-building corals regularly experience changes in intra- and extracellular H+ concentrations ([H+]) due to physiological and environmental processes. Stringent control of [H+] is required to maintain the homeo...

    Authors: Laura Capasso, Philippe Ganot, Víctor Planas-Bielsa, Sylvie Tambutté and Didier Zoccola
    Citation: BMC Molecular and Cell Biology 2021 22:18
  12. Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surfa...

    Authors: Purushottam B. Tiwari, Camelia Bencheqroun, Mario Lemus, Taryn Shaw, Marilyn Kouassi-Brou, Adil Alaoui and Aykut Üren
    Citation: BMC Molecular and Cell Biology 2021 22:17
  13. Staufen2 (STAU2) is an RNA binding protein involved in the posttranscriptional regulation of gene expression. In neurons, STAU2 is required to maintain the balance between differentiation and proliferation of ...

    Authors: Lionel Condé, Yulemi Gonzalez Quesada, Florence Bonnet-Magnaval, Rémy Beaujois and Luc DesGroseillers
    Citation: BMC Molecular and Cell Biology 2021 22:16
  14. Previously, we revealed sexually dimorphic mRNA expression and responsiveness to maternal dietary supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in placentas from a defined INFAT stud...

    Authors: Eva-Maria Sedlmeier, Dorothy M. Meyer, Lynne Stecher, Manuela Sailer, Hannelore Daniel, Hans Hauner and Bernhard L. Bader
    Citation: BMC Molecular and Cell Biology 2021 22:15
  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. Gautron, L. Stapane, N. Le Roy, Y. Nys, A. B. Rodriguez-Navarro and M. T. Hincke
    Citation: BMC Molecular and Cell Biology 2021 22:14

    The original article was published in BMC Molecular and Cell Biology 2021 22:11

  16. Human induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have emerged as potentially viable therapies for spinal cord injuries and...

    Authors: Emilia Solomon, Katie Davis-Anderson, Blake Hovde, Sofiya Micheva-Viteva, Jennifer Foster Harris, Scott Twary and Rashi Iyer
    Citation: BMC Molecular and Cell Biology 2021 22:13
  17. Enterocytes exert an absorptive and protective function in the intestine, and they encounter many different challenging factors such as feed, bacteria, and parasites. An intestinal epithelial in vitro model ca...

    Authors: Federico Ghiselli, Barbara Rossi, Martina Felici, Maria Parigi, Giovanni Tosi, Laura Fiorentini, Paola Massi, Andrea Piva and Ester Grilli
    Citation: BMC Molecular and Cell Biology 2021 22:12
  18. The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds ...

    Authors: J. Gautron, L. Stapane, N. Le Roy, Y. Nys, A. B. Rodriguez-Navarro and M. T. Hincke
    Citation: BMC Molecular and Cell Biology 2021 22:11

    The Correction to this article has been published in BMC Molecular and Cell Biology 2021 22:14

  19. Musashi1 (MSI1) is an oncogenic protein with a crucial role in the proliferation and characteristics of the epithelial cells in breast cancer. The change in expression of MSI1 has a role in solid tumor progressio...

    Authors: Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani and Kamran Ghaedi
    Citation: BMC Molecular and Cell Biology 2021 22:10
  20. Warts, hypogammaglobulinemia, recurrent bacterial infections and myelokathexis (WHIM) syndrome is a primary immunodeficiency disease (PID) usually caused by autosomal dominant mutations in the chemokine receptor

    Authors: Liqing Wang, Qiuhong Xiong, Ping Li, Guangxin Chen, Nayab Tariq and Changxin Wu
    Citation: BMC Molecular and Cell Biology 2021 22:8
  21. One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genom...

    Authors: Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He and Dong Yang
    Citation: BMC Molecular and Cell Biology 2021 22:7
  22. Circular RNAs (circRNAs) are endogenous non-coding RNAs, which are associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529...

    Authors: Xing Zhang, Hongwei Yang, Yingdong Jia, Zhengwen Xu, Liuping Zhang, Meng Sun and Jing Fu
    Citation: BMC Molecular and Cell Biology 2021 22:6
  23. Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these cells have strict controls over their metabolic processes, including...

    Authors: Elisa A. Bonnin, Eugenio F. Fornasiero, Felix Lange, Christoph W. Turck and Silvio O. Rizzoli
    Citation: BMC Molecular and Cell Biology 2021 22:5
  24. Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

    Authors: Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu, Chao Zhang, Huai-Ming Sang, Yan-Yan Liu, Guo-Xin Zhang, Jian-Xia Jiang and Shun-Fu Xu
    Citation: BMC Molecular and Cell Biology 2021 22:4
  25. Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue p...

    Authors: Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada and Masanori Osawa
    Citation: BMC Molecular and Cell Biology 2021 22:3
  26. Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and d...

    Authors: Yasunaga Yoshikawa, Hajime Kozuma, Masami Morimatsu, Kaori Sugawara and Koichi Orino
    Citation: BMC Molecular and Cell Biology 2021 22:2
  27. Culturing primary epithelial cells has a major advantage over tumor-derived or immortalized cell lines as long as their functional phenotype and genetic makeup are mainly maintained. The swine model has shown ...

    Authors: Henry Bautista-Amorocho, Jorge Alexander Silva-Sayago, Diego A. Goyeneche-Patino, Tania Liseth Pérez-Cala, Fabio Macías-Gómez, Juan Carlos Arango-Viana and Alonso Martínez
    Citation: BMC Molecular and Cell Biology 2021 22:1
  28. In rice, the cortex and outer tissues play a key role in submergence tolerance. The cortex differentiates into aerenchyma, which are air-containing cavities that allow the flow of oxygen from shoots to roots, ...

    Authors: Thibault Mounier, Sergi Navarro-Sanz, Charlotte Bureau, Lefeuvre Antoine, Fabrice Varoquaux, Franz Durandet and Christophe Périn
    Citation: BMC Molecular and Cell Biology 2020 21:92
  29. The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse.

    Authors: Weiya Zhang, Juan Ni, Jie Zhang, Lu Zhang, Huanhuan Zhou, Changzhi Zhao, Mengjin Zhu, Haiyan Wang, Jianlin Han, Xinyun Li and Shuhong Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:91
  30. The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymoge...

    Authors: Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton and Carolina De M. Verissimo
    Citation: BMC Molecular and Cell Biology 2020 21:90
  31. Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due to rapid antigenic changes and emergence of new subtypes of influenza...

    Authors: Davod Jafari, Sara Malih, Mohammad Mahmoudi Gomari, Marzieh Safari, Rasool Jafari and Mohammad Morad Farajollahi
    Citation: BMC Molecular and Cell Biology 2020 21:89
  32. Popeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In o...

    Authors: Ian Holt, Heidi R. Fuller, Roland F. R. Schindler, Sally L. Shirran, Thomas Brand and Glenn E. Morris
    Citation: BMC Molecular and Cell Biology 2020 21:88
  33. Caenorhabditis elegans is an excellent model organism for biological research, but its contributions to biochemical elucidation of eukaryotic transcription mechanisms have been limited. One of the biggest obstacl...

    Authors: Phillip Wibisono, Yiyong Liu and Jingru Sun
    Citation: BMC Molecular and Cell Biology 2020 21:87
  34. Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The gen...

    Authors: R. Christian McDonald, Matthew J. Schott, Temitope A. Idowu and Peter J. Lyons
    Citation: BMC Molecular and Cell Biology 2020 21:86
  35. Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident macrophages) form the body’s most effective scavenger cell system for the removal of harmful blood-borne substances, ranging fr...

    Authors: Sabin Bhandari, Ruomei Li, Jaione Simón-Santamaría, Peter McCourt, Steinar Daae Johansen, Bård Smedsrød, Inigo Martinez-Zubiaurre and Karen Kristine Sørensen
    Citation: BMC Molecular and Cell Biology 2020 21:85
  36. Maintenance of centrosome number in cells is essential for accurate distribution of chromosomes at mitosis and is dependent on both proper centrosome duplication during interphase and their accurate distributi...

    Authors: Alan-Michael Bresch, Nadiya Yerich, Rong Wang and Ann O. Sperry
    Citation: BMC Molecular and Cell Biology 2020 21:84
  37. The effects of diverse stresses ultimately alter the structures and functions of proteins. As molecular chaperones, heat shock proteins (HSPs) are a group of highly conserved proteins that help in the refoldin...

    Authors: Xin Zhang, Yuting Li, Yulong Sun, Mingxing Guo, Jianjun Feng, Yilei Wang and Ziping Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:83
  38. Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A fe...

    Authors: Olalekan Olanrewaju Bakare, Marshall Keyster and Ashley Pretorius
    Citation: BMC Molecular and Cell Biology 2020 21:82
  39. Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study is to characterize Tau s...

    Authors: André Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs and Marc H. Mercken
    Citation: BMC Molecular and Cell Biology 2020 21:81
  40. Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fib...

    Authors: Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li and Zheng Chen
    Citation: BMC Molecular and Cell Biology 2020 21:80
  41. Non-professional phagocytosis is usually triggered by stimuli such as necrotic cell death. In tumor therapy, the tumors often disappear slowly and only long time after the end of therapy. Here, tumor therapy i...

    Authors: Dorian Gottwald, Florian Putz, Nora Hohmann, Maike Büttner-Herold, Markus Hecht, Rainer Fietkau and Luitpold Distel
    Citation: BMC Molecular and Cell Biology 2020 21:79
  42. Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (l...

    Authors: Jing Wang, Ming-yue Chen, Jun-feng Chen, Qiao-ling Ren, Jia-qing Zhang, Hai Cao, Bao-song Xing and Chuan-ying Pan
    Citation: BMC Molecular and Cell Biology 2020 21:77
  43. MreB is a bacterial ortholog of actin and forms mobile filaments underneath the cell membrane, perpendicular to the long axis of the cell, which play a crucial role for cell shape maintenance. We wished to vis...

    Authors: Simon Dersch, Christian Reimold, Joshua Stoll, Hannes Breddermann, Thomas Heimerl, Hervé Joel Defeu Soufo and Peter L. Graumann
    Citation: BMC Molecular and Cell Biology 2020 21:76
  44. Many cell permeabilisation methods to mediate internalisation of various molecules to mammalian or bacterial cells have been developed. However, no size-specific permeability assay suitable for both cell types...

    Authors: Yensi Flores Bueso, Sidney Walker, Jennifer Quinn and Mark Tangney
    Citation: BMC Molecular and Cell Biology 2020 21:75
  45. The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a dir...

    Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado and José L. Pablos
    Citation: BMC Molecular and Cell Biology 2020 21:74

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