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  1. In human pancreatic cancer progression, the α6β1-integrin is expressed on cancer cell surface during invasion and metastasis formation. In this study, we investigated whether interleukin (IL)-1α induces the alter...

    Authors: Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama and Tadao Manabe
    Citation: BMC Cell Biology 2006 7:8
    Content type: Research article Published on:

  2. The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells....

    Authors: Olga P Ryabinina, Ezhilkani Subbian and Mihail S Iordanov
    Citation: BMC Cell Biology 2006 7:7
    Content type: Research article Published on:

  3. Despite the great advances in the understanding of programmed cell death, little attention has been paid to the sequence of the events that characterise it. In particular, the course of apoptotic events induce...

    Authors: Francesco Fabbri, Silvia Carloni, Giovanni Brigliadori, Wainer Zoli, Rosa Lapalombella and Marina Marini
    Citation: BMC Cell Biology 2006 7:6
    Content type: Methodology article Published on:

  5. Cutaneous wound repair in adult mammals does not regenerate the original epithelial architecture and results in altered skin function. We propose that lack of regeneration may be due to the absence of appropri...

    Authors: Carrie Fathke, Lynne Wilson, Kavita Shah, Brian Kim, Anne Hocking, Randall Moon and Frank Isik
    Citation: BMC Cell Biology 2006 7:4
    Content type: Research article Published on:

  6. The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at in...

    Authors: Kelly J Langford, Jon M Askham, Tracy Lee, Matthew Adams and Ewan E Morrison
    Citation: BMC Cell Biology 2006 7:3
    Content type: Research article Published on:

  8. Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim exp...

    Authors: Andrew Macdonald, David G Campbell, Rachel Toth, Hilary McLauchlan, C James Hastie and J Simon C Arthur
    Citation: BMC Cell Biology 2006 7:1
    Content type: Research article Published on:

  9. The soil nematode C. elegans survives oxygen-deprived conditions (anoxia; <.001 kPa O2) by entering into a state of suspended animation in which cell cycle progression reversibly arrests. The majority of blastome...

    Authors: Vinita A Hajeri, Jesus Trejo and Pamela A Padilla
    Citation: BMC Cell Biology 2005 6:47
    Content type: Research article Published on:

  10. Copines are soluble, calcium-dependent membrane binding proteins found in a variety of organisms. Copines are characterized as having two C2 domains at the N-terminal region followed by an "A domain" at the C-...

    Authors: Cynthia K Damer, Marina Bayeva, Emily S Hahn, Javier Rivera and Catherine I Socec
    Citation: BMC Cell Biology 2005 6:46
    Content type: Research article Published on:

  11. Cysteine-rich protein 1 (CRP1) is a LIM domain containing protein localized to the nucleus and the actin cytoskeleton. CRP1 has been demonstrated to bind the actin-bundling protein α-actinin and proposed to mo...

    Authors: Thuan C Tran, CoreyAyne Singleton, Tamara S Fraley and Jeffrey A Greenwood
    Citation: BMC Cell Biology 2005 6:45
    Content type: Research article Published on:

  12. Similarities as well as differences in higher order chromatin arrangements of human cell types were previously reported. For an evolutionary comparison, we now studied the arrangements of chromosome territorie...

    Authors: Robert Mayer, Alessandro Brero, Johann von Hase, Timm Schroeder, Thomas Cremer and Steffen Dietzel
    Citation: BMC Cell Biology 2005 6:44
    Content type: Research article Published on:

  13. Ras proteins are guanine-nucleotide-binding enzymes that couple cell surface receptors to intracellular signaling pathways controlling cell proliferation and differentiation, both in lower and higher eukaryote...

    Authors: Maddalena Arigoni, Enrico Bracco, Daniel F Lusche, Helmut Kae, Gerald Weeks and Salvatore Bozzaro
    Citation: BMC Cell Biology 2005 6:43
    Content type: Research article Published on:

  14. Cultures of enterocytes and colonocytes represent valuable tools to study growth and differentiation of epithelial cells. In vitro models may be used to evaluate passage or toxicity of drugs, interactions of e...

    Authors: Dorina Rusu, Suzanne Loret, Olivier Peulen, Jacques Mainil and Guy Dandrifosse
    Citation: BMC Cell Biology 2005 6:42
    Content type: Research article Published on:

  16. The plant peroxisomal multifunctional protein (MFP) possesses up to four enzymatic activities that are involved in catalyzing different reactions of fatty acid β-oxidation in the peroxisome matrix. In addition...

    Authors: Simon DX Chuong, Nam-Il Park, Michelle C Freeman, Robert T Mullen and Douglas G Muench
    Citation: BMC Cell Biology 2005 6:40
    Content type: Research article Published on:

  17. Mammalian blood neutrophilic granulocytes are terminally differentiated cells, possessing extensive heterochromatin and lobulated (or ring-shaped) nuclei. Despite the extensive amount of heterochromatin, neutr...

    Authors: Donald E Olins and Ada L Olins
    Citation: BMC Cell Biology 2005 6:39
    Content type: Research article Published on:

  18. The microenvironment surrounding cells can exert multiple effects on their biological responses. In particular the extracellular matrix surrounding cells can profoundly influence their behavior. It has been sh...

    Authors: Christina L Addison, Jacques E Nör, Huijun Zhao, Stephanie A Linn, Peter J Polverini and Christie E Delaney
    Citation: BMC Cell Biology 2005 6:38
    Content type: Research article Published on:

  19. Normal cells possess a limited proliferative life span after which they enter a state of irreversible growth arrest. This process, known as replicative senescence, is accompanied by changes in gene expression ...

    Authors: Robert F Place, Emily J Noonan and Charles Giardina
    Citation: BMC Cell Biology 2005 6:37
    Content type: Research article Published on:

  20. The actin cytoskeleton participates in many fundamental processes including the regulation of cell shape, motility, and adhesion. The remodeling of the actin cytoskeleton is dependent on actin binding proteins...

    Authors: Julaine Roffers-Agarwal, Jennifer B Xanthos and Jeffrey R Miller
    Citation: BMC Cell Biology 2005 6:36
    Content type: Research article Published on:

  21. Members of the Kinesin-3 family of kinesin-like proteins mediate transport of axonal vesicles (KIF1A, KIF1Bβ), distribution of mitochondria (KIF1Bα) and anterograde Golgi to ER vesicle transport (KIF1C). Until...

    Authors: Marcin J Wozniak, Martina Melzer, Cornelia Dorner, Hans-Ulrich Haring and Reiner Lammers
    Citation: BMC Cell Biology 2005 6:35
    Content type: Research article Published on:

  22. Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. The huntingtin protein expressed from HD has an unknown function but is suggested to interact ...

    Authors: Åsa Petersén, Ylva Stewénius, Maria Björkqvist and David Gisselsson
    Citation: BMC Cell Biology 2005 6:34
    Content type: Research article Published on:

  23. Hermansky-Pudlak syndrome (HPS) is a disorder of lysosome-related organelle biogenesis characterized by oculocutaneous albinism and prolonged bleeding. These clinical findings reflect defects in the formation ...

    Authors: Amanda Helip-Wooley, Wendy Westbroek, Heidi Dorward, Mieke Mommaas, Raymond E Boissy, William A Gahl and Marjan Huizing
    Citation: BMC Cell Biology 2005 6:33
    Content type: Research article Published on:

  25. Adhesion to extracellular matrix (ECM) components has been implicated in the proliferative and invasive properties of tumor cells. We investigated the ability of C6 glioma cells to attach to ECM components in vit...

    Authors: Claudia Beatriz Nedel Mendes de Aguiar, Bruno Lobão-Soares, Marcio Alvarez-Silva and Andréa Gonçalves Trentin
    Citation: BMC Cell Biology 2005 6:31
    Content type: Research article Published on:

  26. The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. ...

    Authors: Robyn M Carey, Brigitte A Balcz, Ignacio Lopez-Coviella and Barbara E Slack
    Citation: BMC Cell Biology 2005 6:30
    Content type: Research article Published on:

  27. The Cajal body (CB) is a nuclear suborganelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are vital for pre-mRNA splicing. Newly imported Sm-class snRNPs traffic through CBs,...

    Authors: Hongzhi Xu, Z Brad Somers, Melvin L Robinson II and Michael D Hebert
    Citation: BMC Cell Biology 2005 6:29
    Content type: Research article Published on:

  28. SMC proteins are key components of several protein complexes that perform vital tasks in different chromosome dynamics. Bacterial SMC forms a complex with ScpA and ScpB that is essential for chromosome arrange...

    Authors: Judita Mascarenhas, Arsen V Volkov, Cornelia Rinn, Jens Schiener, Reinhard Guckenberger and Peter L Graumann
    Citation: BMC Cell Biology 2005 6:28
    Content type: Research article Published on:

  29. Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptu...

    Authors: Mauro Paradisi, Dayle McClintock, Revekka L Boguslavsky, Christina Pedicelli, Howard J Worman and Karima Djabali
    Citation: BMC Cell Biology 2005 6:27
    Content type: Research article Published on:

  31. During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process p...

    Authors: Jun Zhou, Ping Zhu, Jian Li Jiang, Qing Zhang, Zhen Biao Wu, Xi Ying Yao, Hao Tang, Ning Lu, Yong Yang and Zhi Nan Chen
    Citation: BMC Cell Biology 2005 6:25
    Content type: Research article Published on:

  32. Guanylic nucleotides are both macromolecules constituents and crucial regulators for a variety of cellular processes. Therefore, their intracellular concentration must be strictly controlled. Consistently both...

    Authors: Isabelle Sagot, Jacques Schaeffer and Bertrand Daignan-Fornier
    Citation: BMC Cell Biology 2005 6:24
    Content type: Research article Published on:

  34. Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCα) with caveolin in CHO cells. PKCα is found widely in the cytoplasm and nucl...

    Authors: Christopher D Stubbs, Stanley W Botchway, Simon J Slater and Anthony W Parker
    Citation: BMC Cell Biology 2005 6:22
    Content type: Research article Published on:

  35. Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs). To gain ...

    Authors: Tarja Kokkola, Juha R Savinainen, Kati S Mönkkönen, Montse Durán Retamal and Jarmo T Laitinen
    Citation: BMC Cell Biology 2005 6:21
    Content type: Research article Published on:

  36. Human cell types respond differently to infection by human immunodeficiency virus (HIV). Defining specific interactions between host cells and viral proteins is essential in understanding how viruses exploit c...

    Authors: Susanne Kramer-Hämmerle, Francesca Ceccherini-Silberstein, Christian Bickel, Horst Wolff, Michelle Vincendeau, Thomas Werner, Volker Erfle and Ruth Brack-Werner
    Citation: BMC Cell Biology 2005 6:20
    Content type: Research article Published on:

  37. Time-lapse microscopic imaging provides a powerful approach for following changes in cell phenotype over time. Visible responses of whole cells can yield insight into functional changes that underlie physiolog...

    Authors: Alfred Bahnson, Charalambos Athanassiou, Douglas Koebler, Lei Qian, Tongying Shun, Donna Shields, Hui Yu, Hong Wang, Julie Goff, Tao Cheng, Raymond Houck and Lex Cowsert
    Citation: BMC Cell Biology 2005 6:19
    Content type: Methodology article Published on:

  38. A number of transgenic mice carrying different deletions in the Locus Control Region (LCR) of the mouse tyrosinase (Tyr) gene have been developed and analysed in our laboratory. We require melanocytes from these ...

    Authors: Alfonso Lavado, Ander Matheu, Manuel Serrano and Lluís Montoliu
    Citation: BMC Cell Biology 2005 6:18
    Content type: Methodology article Published on:

  39. EB1 is a microtubule tip-associated protein that interacts with the APC tumour suppressor protein and the p150glued subunit of dynactin. We previously reported that an EB1 deletion mutant that retains both of ...

    Authors: Nick P Riess, Kelly Milward, Tracy Lee, Matthew Adams, Jon M Askham and Ewan E Morrison
    Citation: BMC Cell Biology 2005 6:17
    Content type: Research article Published on:

  40. Splicing variants of human cathepsinB primary transcripts (CB(-2,3)) result in an expression product product which lacks the signal peptide and parts of the propeptide. This naturally truncated Δ51CB is thus unab...

    Authors: Felix Bestvater, Claudia Dallner and Eberhard Spiess
    Citation: BMC Cell Biology 2005 6:16
    Content type: Research article Published on:

  41. The small GTPase rab1a and its isoform rab1b are essential regulating components in the vesicle transport between the ER and the Golgi apparatus. Rab1 is thought to act as a molecular switch and can change bet...

    Authors: Michael Bayer, Julia Fischer, Joachim Kremerskothen, Edith Ossendorf, Theodoros Matanis, Magdalena Konczal, Thomas Weide and Angelika Barnekow
    Citation: BMC Cell Biology 2005 6:15
    Content type: Research article Published on:

  43. Stimulation of Dictyostelium discoideum with cAMP evokes an elevation of the cytosolic free Ca2+ concentration ([Ca2+]i). The [Ca2+]i-change is composed of liberation of stored Ca2+ and extracellular Ca2+-entry. ...

    Authors: Ralph H Schaloske, Daniel F Lusche, Karen Bezares-Roder, Kathrin Happle, Dieter Malchow and Christina Schlatterer
    Citation: BMC Cell Biology 2005 6:13
    Content type: Research article Published on:

  44. Differentiating Dictyostelium discoideum amoebae respond upon cAMP-stimulation with an increase in the cytosolic free Ca2+ concentration ([Ca2+]i) that is composed of liberation of stored Ca2+ and extracellular C...

    Authors: Daniel F Lusche, Karen Bezares-Roder, Kathrin Happle and Christina Schlatterer
    Citation: BMC Cell Biology 2005 6:12
    Content type: Research article Published on:

  45. The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream o...

    Authors: Craig F Stovold, Thomas H Millard and Laura M Machesky
    Citation: BMC Cell Biology 2005 6:11
    Content type: Research article Published on:

  46. Bacterial actin-like proteins have been shown to perform essential functions in several aspects of cellular physiology. They affect cell growth, cell shape, chromosome segregation and polar localization of pro...

    Authors: Hervé Joël Defeu Soufo and Peter L Graumann
    Citation: BMC Cell Biology 2005 6:10
    Content type: Research article Published on:

  48. The growth of new blood vessels in adult life requires the initiation of endothelial cell migration and proliferation from pre-existing vessels in addition to the recruitment and differentiation of circulating...

    Authors: Salman Rahman, Yatin Patel, Jacqueline Murray, Kirti V Patel, Rushika Sumathipala, Michael Sobel and Errol S Wijelath
    Citation: BMC Cell Biology 2005 6:8
    Content type: Research article Published on:

  49. Gliomas are "intraparenchymally metastatic" tumors, invading the brain in a non-destructive way that suggests cooperation between glioma cells and their environment. Recent studies using an engineered rodent C...

    Authors: Roxane Oliveira, Christo Christov, Jean Sébastien Guillamo, Sophie de Boüard, Stéphane Palfi, Laurent Venance, Marcienne Tardy and Marc Peschanski
    Citation: BMC Cell Biology 2005 6:7
    Content type: Research article Published on:
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