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  1. The present study was carried out to determine whether the p53 pathway played a role in the spontaneous immortalization of the SC-2 chicken embryo fibroblast (CEF) cell line that has been in continuous culture...

    Authors: Shelly A Christman, Byung-Whi Kong, Megan M Landry, Hyunggee Kim and Douglas N Foster
    Citation: BMC Cell Biology 2006 7:27
  2. Studying mitosis requires a system in which the dramatic movements of chromosomes and spindle microtubules can be visualized. PtK cells, due to their flat morphology and their small number of large chromosomes...

    Authors: Jane R Stout, Rania S Rizk, Susan L Kline and Claire E Walczak
    Citation: BMC Cell Biology 2006 7:26
  3. Single-cell level studies are being used increasingly to measure cell properties not directly observable in a cell population. High-performance data acquisition systems for such studies have, by necessity, dev...

    Authors: Kiyoshi Ohnuma, Tetsuya Yomo, Makoto Asashima and Kunihiko Kaneko
    Citation: BMC Cell Biology 2006 7:25
  4. Integrins comprise a large family of α,β heterodimeric, transmembrane cell adhesion receptors that mediate diverse essential biological functions. Higher vertebrates possess a single β1 gene, and the β1 subuni...

    Authors: A Paul Mould, Jennifer A McLeish, Julie Huxley-Jones, Alexander C Goonesinghe, Adam FL Hurlstone, Raymond P Boot-Handford and Martin J Humphries
    Citation: BMC Cell Biology 2006 7:24
  5. There exists abundant molecular and ultra-structural evidence to suggest that cytoplasmic actin can physically interact with the nuclear envelope (NE) membrane system. However, this interaction has yet to be c...

    Authors: Sylvia Münter, Jost Enninga, Rafael Vazquez-Martinez, Erwan Delbarre, Brigitte David-Watine, Ulf Nehrbass and Spencer L Shorte
    Citation: BMC Cell Biology 2006 7:23
  6. The pim family genes encode oncogenic serine/threonine kinases which in hematopoietic cells have been implicated in cytokine-dependent signaling as well as in lymphomagenesis, especially in cooperation with other...

    Authors: Teija LT Aho, Jouko Sandholm, Katriina J Peltola, Yoshiaki Ito and Päivi J Koskinen
    Citation: BMC Cell Biology 2006 7:21
  7. The absorptive and goblet cells are the main cellular types encountered in the intestine epithelium. The cell lineage Caco-2 is a model commonly used to reproduce the features of the bowel epithelium. However,...

    Authors: Géraldine Nollevaux, Christelle Devillé, Benaïssa El Moualij, Willy Zorzi, Patricia Deloyer, Yves-Jacques Schneider, Olivier Peulen and Guy Dandrifosse
    Citation: BMC Cell Biology 2006 7:20
  8. Gene transcriptional activity is well correlated with intra-nuclear position, especially relative to the nuclear periphery, which is a region classically associated with gene silencing. Recently however, activ...

    Authors: David A Drubin, Arman M Garakani and Pamela A Silver
    Citation: BMC Cell Biology 2006 7:19
  9. Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in mo...

    Authors: Olivier Hagens, Andrea Ballabio, Vera Kalscheuer, Jean-Pierre Kraehenbuhl, M Vittoria Schiaffino, Peter Smith, Olivier Staub, Jeff Hildebrand and John B Wallingford
    Citation: BMC Cell Biology 2006 7:18
  10. Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood. As nitric oxide is involved in angiogenesis, we speculate...

    Authors: KP Tamilarasan, Gopi Krishna Kolluru, Megha Rajaram, M Indhumathy, R Saranya and Suvro Chatterjee
    Citation: BMC Cell Biology 2006 7:17
  11. In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides di...

    Authors: Gudrun Valdimarsdottir, Marie-José Goumans, Fumiko Itoh, Susumu Itoh, Carl-Henrik Heldin and Peter ten Dijke
    Citation: BMC Cell Biology 2006 7:16
  12. Transforming Growth Factor-β (TGF-β) regulates key biological processes during development and in adult tissues and has been implicated in many diseases. To study the biological functions of TGF-β, sensitive, ...

    Authors: Ina Tesseur, Kun Zou, Elisabeth Berber, Hui Zhang and Tony Wyss-Coray
    Citation: BMC Cell Biology 2006 7:15
  13. A hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow (BM) necessitates their in vitro expansion prior...

    Authors: Mandana Mohyeddin Bonab, Kamran Alimoghaddam, Fatemeh Talebian, Syed Hamid Ghaffari, Ardeshir Ghavamzadeh and Behrouz Nikbin
    Citation: BMC Cell Biology 2006 7:14
  14. Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional complex (AJC) which regulates cell-cell adhesion, paracellular permeability and cell polarity. The AJC is anchored on cytosk...

    Authors: Andrei I Ivanov, Ingrid C McCall, Brian Babbin, Stanislav N Samarin, Asma Nusrat and Charles A Parkos
    Citation: BMC Cell Biology 2006 7:12
  15. Cell differentiation has long been theorized to represent a switch in a bistable system, and recent experimental work in micro-organisms has revealed bistable dynamics in small gene regulatory circuits. Howeve...

    Authors: Hannah H Chang, Philmo Y Oh, Donald E Ingber and Sui Huang
    Citation: BMC Cell Biology 2006 7:11
  16. Notch plays a wide-ranging role in controlling cell fate, differentiation and development. The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, pr...

    Authors: Grahame Mckenzie, George Ward, Yvette Stallwood, Emmanuel Briend, Sofia Papadia, Andrew Lennard, Martin Turner, Brian Champion and Giles E Hardingham
    Citation: BMC Cell Biology 2006 7:10
  17. The biochemical bases for hormone dependence in breast cancer have been recognized as an important element in tumor resistance, proliferation and metastasis. On this respect, dexamethasone (Dex) dependent prot...

    Authors: Catalina Machuca, Criselda Mendoza-Milla, Emilio Córdova, Salvador Mejía, Luis Covarrubias, José Ventura and Alejandro Zentella
    Citation: BMC Cell Biology 2006 7:9
  18. In human pancreatic cancer progression, the α6β1-integrin is expressed on cancer cell surface during invasion and metastasis formation. In this study, we investigated whether interleukin (IL)-1α induces the alter...

    Authors: Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama and Tadao Manabe
    Citation: BMC Cell Biology 2006 7:8
  19. The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells....

    Authors: Olga P Ryabinina, Ezhilkani Subbian and Mihail S Iordanov
    Citation: BMC Cell Biology 2006 7:7
  20. Despite the great advances in the understanding of programmed cell death, little attention has been paid to the sequence of the events that characterise it. In particular, the course of apoptotic events induce...

    Authors: Francesco Fabbri, Silvia Carloni, Giovanni Brigliadori, Wainer Zoli, Rosa Lapalombella and Marina Marini
    Citation: BMC Cell Biology 2006 7:6
  21. Cutaneous wound repair in adult mammals does not regenerate the original epithelial architecture and results in altered skin function. We propose that lack of regeneration may be due to the absence of appropri...

    Authors: Carrie Fathke, Lynne Wilson, Kavita Shah, Brian Kim, Anne Hocking, Randall Moon and Frank Isik
    Citation: BMC Cell Biology 2006 7:4
  22. The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at in...

    Authors: Kelly J Langford, Jon M Askham, Tracy Lee, Matthew Adams and Ewan E Morrison
    Citation: BMC Cell Biology 2006 7:3
  23. Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim exp...

    Authors: Andrew Macdonald, David G Campbell, Rachel Toth, Hilary McLauchlan, C James Hastie and J Simon C Arthur
    Citation: BMC Cell Biology 2006 7:1
  24. The soil nematode C. elegans survives oxygen-deprived conditions (anoxia; <.001 kPa O2) by entering into a state of suspended animation in which cell cycle progression reversibly arrests. The majority of blastome...

    Authors: Vinita A Hajeri, Jesus Trejo and Pamela A Padilla
    Citation: BMC Cell Biology 2005 6:47
  25. Copines are soluble, calcium-dependent membrane binding proteins found in a variety of organisms. Copines are characterized as having two C2 domains at the N-terminal region followed by an "A domain" at the C-...

    Authors: Cynthia K Damer, Marina Bayeva, Emily S Hahn, Javier Rivera and Catherine I Socec
    Citation: BMC Cell Biology 2005 6:46
  26. Cysteine-rich protein 1 (CRP1) is a LIM domain containing protein localized to the nucleus and the actin cytoskeleton. CRP1 has been demonstrated to bind the actin-bundling protein α-actinin and proposed to mo...

    Authors: Thuan C Tran, CoreyAyne Singleton, Tamara S Fraley and Jeffrey A Greenwood
    Citation: BMC Cell Biology 2005 6:45
  27. Similarities as well as differences in higher order chromatin arrangements of human cell types were previously reported. For an evolutionary comparison, we now studied the arrangements of chromosome territorie...

    Authors: Robert Mayer, Alessandro Brero, Johann von Hase, Timm Schroeder, Thomas Cremer and Steffen Dietzel
    Citation: BMC Cell Biology 2005 6:44
  28. Ras proteins are guanine-nucleotide-binding enzymes that couple cell surface receptors to intracellular signaling pathways controlling cell proliferation and differentiation, both in lower and higher eukaryote...

    Authors: Maddalena Arigoni, Enrico Bracco, Daniel F Lusche, Helmut Kae, Gerald Weeks and Salvatore Bozzaro
    Citation: BMC Cell Biology 2005 6:43
  29. Cultures of enterocytes and colonocytes represent valuable tools to study growth and differentiation of epithelial cells. In vitro models may be used to evaluate passage or toxicity of drugs, interactions of e...

    Authors: Dorina Rusu, Suzanne Loret, Olivier Peulen, Jacques Mainil and Guy Dandrifosse
    Citation: BMC Cell Biology 2005 6:42
  30. The plant peroxisomal multifunctional protein (MFP) possesses up to four enzymatic activities that are involved in catalyzing different reactions of fatty acid β-oxidation in the peroxisome matrix. In addition...

    Authors: Simon DX Chuong, Nam-Il Park, Michelle C Freeman, Robert T Mullen and Douglas G Muench
    Citation: BMC Cell Biology 2005 6:40
  31. Mammalian blood neutrophilic granulocytes are terminally differentiated cells, possessing extensive heterochromatin and lobulated (or ring-shaped) nuclei. Despite the extensive amount of heterochromatin, neutr...

    Authors: Donald E Olins and Ada L Olins
    Citation: BMC Cell Biology 2005 6:39
  32. The microenvironment surrounding cells can exert multiple effects on their biological responses. In particular the extracellular matrix surrounding cells can profoundly influence their behavior. It has been sh...

    Authors: Christina L Addison, Jacques E Nör, Huijun Zhao, Stephanie A Linn, Peter J Polverini and Christie E Delaney
    Citation: BMC Cell Biology 2005 6:38
  33. Normal cells possess a limited proliferative life span after which they enter a state of irreversible growth arrest. This process, known as replicative senescence, is accompanied by changes in gene expression ...

    Authors: Robert F Place, Emily J Noonan and Charles Giardina
    Citation: BMC Cell Biology 2005 6:37
  34. The actin cytoskeleton participates in many fundamental processes including the regulation of cell shape, motility, and adhesion. The remodeling of the actin cytoskeleton is dependent on actin binding proteins...

    Authors: Julaine Roffers-Agarwal, Jennifer B Xanthos and Jeffrey R Miller
    Citation: BMC Cell Biology 2005 6:36
  35. Members of the Kinesin-3 family of kinesin-like proteins mediate transport of axonal vesicles (KIF1A, KIF1Bβ), distribution of mitochondria (KIF1Bα) and anterograde Golgi to ER vesicle transport (KIF1C). Until...

    Authors: Marcin J Wozniak, Martina Melzer, Cornelia Dorner, Hans-Ulrich Haring and Reiner Lammers
    Citation: BMC Cell Biology 2005 6:35
  36. Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. The huntingtin protein expressed from HD has an unknown function but is suggested to interact ...

    Authors: Åsa Petersén, Ylva Stewénius, Maria Björkqvist and David Gisselsson
    Citation: BMC Cell Biology 2005 6:34
  37. Hermansky-Pudlak syndrome (HPS) is a disorder of lysosome-related organelle biogenesis characterized by oculocutaneous albinism and prolonged bleeding. These clinical findings reflect defects in the formation ...

    Authors: Amanda Helip-Wooley, Wendy Westbroek, Heidi Dorward, Mieke Mommaas, Raymond E Boissy, William A Gahl and Marjan Huizing
    Citation: BMC Cell Biology 2005 6:33
  38. Adhesion to extracellular matrix (ECM) components has been implicated in the proliferative and invasive properties of tumor cells. We investigated the ability of C6 glioma cells to attach to ECM components in vit...

    Authors: Claudia Beatriz Nedel Mendes de Aguiar, Bruno Lobão-Soares, Marcio Alvarez-Silva and Andréa Gonçalves Trentin
    Citation: BMC Cell Biology 2005 6:31
  39. The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. ...

    Authors: Robyn M Carey, Brigitte A Balcz, Ignacio Lopez-Coviella and Barbara E Slack
    Citation: BMC Cell Biology 2005 6:30
  40. The Cajal body (CB) is a nuclear suborganelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are vital for pre-mRNA splicing. Newly imported Sm-class snRNPs traffic through CBs,...

    Authors: Hongzhi Xu, Z Brad Somers, Melvin L Robinson II and Michael D Hebert
    Citation: BMC Cell Biology 2005 6:29
  41. SMC proteins are key components of several protein complexes that perform vital tasks in different chromosome dynamics. Bacterial SMC forms a complex with ScpA and ScpB that is essential for chromosome arrange...

    Authors: Judita Mascarenhas, Arsen V Volkov, Cornelia Rinn, Jens Schiener, Reinhard Guckenberger and Peter L Graumann
    Citation: BMC Cell Biology 2005 6:28
  42. Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptu...

    Authors: Mauro Paradisi, Dayle McClintock, Revekka L Boguslavsky, Christina Pedicelli, Howard J Worman and Karima Djabali
    Citation: BMC Cell Biology 2005 6:27
  43. During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process p...

    Authors: Jun Zhou, Ping Zhu, Jian Li Jiang, Qing Zhang, Zhen Biao Wu, Xi Ying Yao, Hao Tang, Ning Lu, Yong Yang and Zhi Nan Chen
    Citation: BMC Cell Biology 2005 6:25

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