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406 result(s) for 'apoptosis' within BMC Molecular and Cell Biology

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  1. Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fib...

    Authors: Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li and Zheng Chen
    Citation: BMC Molecular and Cell Biology 2020 21:80
    Content type: Research article Published on:

  3. Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulatio...

    Authors: Yan Li, Yong Liu, Kailong Wang, Yinghui Huang, Wenhao Han, Jiachuan Xiong, Ke Yang, Mingying Liu, Tangli Xiao, Chi Liu, Ting He, Xianjin Bi, Jingbo Zhang, Bo Zhang and Jinghong Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:45
    Content type: Research article Published on:

  4. Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endot...

    Authors: Michaela Beese, Kristin Wyss, Marion Haubitz and Torsten Kirsch
    Citation: BMC Cell Biology 2010 11:68
    Content type: Research article Published on:

  6. The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells....

    Authors: Olga P Ryabinina, Ezhilkani Subbian and Mihail S Iordanov
    Citation: BMC Cell Biology 2006 7:7
    Content type: Research article Published on:

  7. The lymphatic system complements the blood circulatory system in absorption and transport of nutrients, and in the maintenance of homeostasis. Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angio...

    Authors: Vicky PKH Nguyen, Stephen H Chen, Jason Trinh, Harold Kim, Brenda L Coomber and Daniel J Dumont
    Citation: BMC Cell Biology 2007 8:10
    Content type: Research article Published on:

  8. The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with in...

    Authors: Marzia Tagliaferro, Paolo Rosa, Gian Carlo Bellenchi, Daniela Bastianelli, Rosa Trotta, Claudia Tito, Francesco Fazi, Antonella Calogero and Donatella Ponti
    Citation: BMC Molecular and Cell Biology 2022 23:13
    Content type: Research Published on:

  9. The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of apical domains of epithelial cells, is key to the development of complex cellular pattern...

    Authors: Andy Zhao, Sophia Varady, Madelyn O’Kelley-Bangsberg, Vicki Deng, Amy Platenkamp, Petra Wijngaard, Miriam Bern, Wyatt Gormley, Elaine Kushkowski, Kat Thompson, Logan Tibbetts, A. Tamar Conner, David Noeckel, Aidan Teran, Anna Ritz and Derek A. Applewhite
    Citation: BMC Molecular and Cell Biology 2023 24:32
    Content type: Research Published on:

  10. Advanced glycation end products generated in the circulation of diabetic patients were reported to affect the function of vascular wall. We examined the effects of advanced glycation end products-bovine serum ...

    Authors: Chi-Young Wang, Hung-Jen Liu, Heng-Ju Chen, Yi-Chun Lin, Hsueh-Hsiao Wang, Ta-Chuan Hung and Hung-I Yeh
    Citation: BMC Cell Biology 2011 12:19
    Content type: Research article Published on:

  11. Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein L11 (RPL11) is a component of ribosomal 60 S large subunit with diffe...

    Authors: Jie Chen, Changda Lei, Huahua Zhang, Xiaoyong Huang, Yang Yang, Junli Liu, Yuna Jia, Haiyan Shi, Yunqing Zhang, Jing Zhang and Juan Du
    Citation: BMC Molecular and Cell Biology 2023 24:7
    Content type: Research Published on:

  12. The guanine nucleotide exchange factor C3G (RapGEF1) along with its effector proteins participates in signaling pathways that regulate eukaryotic cell proliferation, adhesion, apoptosis and embryonic development....

    Authors: Vegesna Radha, Ajumeera Rajanna and Ghanshyam Swarup
    Citation: BMC Cell Biology 2004 5:31
    Content type: Research article Published on:

  14. Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer’s disease (AD). Recent evidence has suggested that ...

    Authors: Allaura S. Cone, Stephanie N. Hurwitz, Gloria S. Lee, Xuegang Yuan, Yi Zhou, Yan Li and David G. Meckes Jr
    Citation: BMC Molecular and Cell Biology 2020 21:58
    Content type: Research article Published on:

  15. Renal podocytes form the main filtration barrier possessing a unique phenotype maintained by proteins including podocalyxin and nephrin, the expression of which is suppressed in pathological conditions. We use...

    Authors: Nikolaos E Tsotakos, Marina Sagnou, Eleni S Kotsopoulou, Effie C Tsilibary and Garyfalia I Drossopoulou
    Citation: BMC Cell Biology 2013 14:28
    Content type: Research article Published on:

  16. Promyelocytic Leukemia (PML) protein can interact with a multitude of cellular factors and has been implicated in the regulation of various processes, including protein sequestration, cell cycle regulation and...

    Authors: Diarmuid M Moran, Hong Shen and Carl G Maki
    Citation: BMC Cell Biology 2009 10:32
    Content type: Research article Published on:

  17. Endometriosis is one of the most common gynecological diseases, and seriously reduces the quality of life of patients. However, the pathogenesis of this disease is unclear. Therefore, more studies are needed t...

    Authors: Yanan He, J. Wang, Xinyan Jiang, Jianhua Gao, Yan Cheng, Tian Liang, Jun Zhou, Liyuan Sun and Guangmei Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:37
    Content type: Research Published on:

  18. Previously published reports indicated that some enzymes of the central carbon metabolism (CCM), particularly those involved in glycolysis and the tricarboxylic acid cycle, may contribute to regulation of DNA ...

    Authors: Aleksandra Konieczna, Aneta Szczepańska, Karolina Sawiuk, Grzegorz Węgrzyn and Robert Łyżeń
    Citation: BMC Cell Biology 2015 16:16
    Content type: Research article Published on:

  19. External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role. Prev...

    Authors: Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang, Xin Wang and Shujuan Zou
    Citation: BMC Cell Biology 2017 18:19
    Content type: Research article Published on:

  20. Matrix mineralization is a key stage in bone formation involving in many bone-specific genes and signaling pathways. Emerging evidence indicate that long non-coding RNA (lncRNA) and microRNAs (miRNAs) play cru...

    Authors: Yuan Wu, Yu Jiang, Qiang Liu and Cui-Zhong Liu
    Citation: BMC Molecular and Cell Biology 2019 20:48
    Content type: Research article Published on:

  21. Hypertrophic cardiomyopathy occurs along with pathological phenomena such as cardiac hypertrophy, myocardial fibrosis and cardiomyocyte activity. However, few of the specific molecular mechanisms underlying th...

    Authors: Xin Liu, Lin Lin, Qing Li, Yajuan Ni, Chaoying Zhang, Shuguang Qin and Jin Wei
    Citation: BMC Molecular and Cell Biology 2019 20:14
    Content type: Research article Published on:

  22. Skeletal muscle differentiation is a multistep, complex pathway in which several important signaling molecules are involved. Recently, microRNAs (miRNAs), endogenous non-coding small RNAs that regulate mRNAs, ...

    Authors: Naoki Katase, Kumiko Terada, Takahiro Suzuki, Shin-ichiro Nishimatsu and Tsutomu Nohno
    Citation: BMC Cell Biology 2015 16:13
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cell Biology 2016 17:9

  23. MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Authors: Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu
    Citation: BMC Cell Biology 2017 18:9
    Content type: Research article Published on:

  24. Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers of wide spectrum of haemo- and immunoregulatory cytokines. The aim of the current work was to co...

    Authors: Sergey V Sennikov, Tatyana V Injelevskaya, Sergey V Krysov, Alexandr N Silkov, Igor B Kovinev, Natalya J Dyachkova, Anton N Zenkov, Mary I Loseva and Vladimir A Kozlov
    Citation: BMC Cell Biology 2004 5:39
    Content type: Research article Published on:

  25. Cryopreservation of human spermatozoa has been identified as an efficient procedure to preserve fertility in men before any cancer therapy or surgical infertility treatment. Despite the benefits of the procedu...

    Authors: Fatemeh Eini, Maryam Azizi kutenaei, Maryam Hosseinzadeh Shirzeyli, Zeinolabedin Sharifian Dastjerdi, Mahmoud Omidi and Marefat Ghaffari Novin
    Citation: BMC Molecular and Cell Biology 2021 22:50
    Content type: Research Published on:

  26. Transforming Growth Factor-β (TGF-β) regulates key biological processes during development and in adult tissues and has been implicated in many diseases. To study the biological functions of TGF-β, sensitive, ...

    Authors: Ina Tesseur, Kun Zou, Elisabeth Berber, Hui Zhang and Tony Wyss-Coray
    Citation: BMC Cell Biology 2006 7:15
    Content type: Methodology article Published on:

  27. A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting...

    Authors: Maki Murata-Hori, Greenfield Sluder and Yu-li Wang
    Citation: BMC Cell Biology 2004 5:49
    Content type: Research article Published on:

  28. In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...

    Authors: Jafar Rezaie, Mojtaba Jahanghiri, Reza Mosaddeghi- Heris, Sina Hassannezhad, Nima Abdyazdani, Afshin Rahbarghazi and Mahdi Ahmadi
    Citation: BMC Molecular and Cell Biology 2024 25:7
    Content type: Research Published on:

  29. Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving en...

    Authors: Kaixin Qiu, Wenping Liang, Shuai Wang, Tingting Kong, Xin Wang, Chunyan Li, Zhe Wang and Yili Wu
    Citation: BMC Molecular and Cell Biology 2020 21:13
    Content type: Research article Published on:

  30. Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeleta...

    Authors: Yael Fridmann-Sirkis, Symeon Siniossoglou and Hugh RB Pelham
    Citation: BMC Cell Biology 2004 5:18
    Content type: Research article Published on:

  31. The platelet cytoskeleton mediates the dramatic change in platelet morphology that takes place upon activation and stabilizes thrombus formation. The Arp2/3 complex plays a vital role in these processes, provi...

    Authors: Steven G Thomas, Simon DJ Calaminus, Jocelyn M Auger, Stephen P Watson and Laura M Machesky
    Citation: BMC Cell Biology 2007 8:46
    Content type: Research article Published on:

  33. Transforming growth factor-βs (TGF-βs), bone morphogenetic proteins (BMPs) and activins are important regulators of developmental cell growth and differentiation. Signaling by these factors is mediated chiefly...

    Authors: Nieves Ibarrola, Irina Kratchmarova, Daisuke Nakajima, William P Schiemann, Aristidis Moustakas, Akhilesh Pandey and Matthias Mann
    Citation: BMC Cell Biology 2004 5:2
    Content type: Research article Published on:

  34. Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglyc...

    Authors: Fangzi Gong, Le Gao, Luyao Ma, Guangxin Li and Jianhong Yang
    Citation: BMC Molecular and Cell Biology 2021 22:24
    Content type: Research Published on:

  35. CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers. Many CtBP-regulated proteins are involve...

    Authors: Lee M Bergman, Laila Morris, Matthew Darley, Alexander H Mirnezami, Samal C Gunatilake and Jeremy P Blaydes
    Citation: BMC Cell Biology 2006 7:35
    Content type: Research article Published on:

  36. Green fluorescent protein (GFP) and other FP fusions have been extensively utilized to track protein dynamics in living cells. Recently, development of photoactivatable, photoswitchable and photoconvertible fl...

    Authors: Susan M Baker, Robert W Buckheit III and Matthias M Falk
    Citation: BMC Cell Biology 2010 11:15
    Content type: Methodology article Published on:

  37. α1-antitrypsin (AAT) is one of the major serine proteinase inhibitors controlling proteinases in many biological pathways. There is increasing evidence that AAT is able to exert other than antiproteolytic effe...

    Authors: Ruta Aldonyte, Lennart Jansson and Sabina Janciauskiene
    Citation: BMC Cell Biology 2004 5:11
    Content type: Research article Published on:

  38. Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...

    Authors: Young Hwa Soung, Nadejda Korneeva, Tae Hyong Kim and Jun Chung
    Citation: BMC Cell Biology 2013 14:49
    Content type: Research article Published on:

  39. Placement of a cultured synovial mesenchymal stem cell (MSC) suspension on a repaired meniscus for 10 min accelerated meniscus repair. Upon placement of the MSC suspension on the meniscus, microspikes projecti...

    Authors: Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga and Ichiro Sekiya
    Citation: BMC Molecular and Cell Biology 2022 23:53
    Content type: Research article Published on:

  40. MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse...

    Authors: Jack D. Sanford, Jing Yang, Jing Han, Laura A. Tollini, Aiwen Jin and Yanping Zhang
    Citation: BMC Molecular and Cell Biology 2021 22:46
    Content type: Research Published on:

  41. Many attempts are used to discover mechanisms driving impaired angiogenesis in age-related diseases. Angiogenesis is highly regulated by different signaling pathways. Here, we investigated the angiogenesis pot...

    Authors: Nesa Janamo Berenjabad, Vahid Nejati and Jafar Rezaie
    Citation: BMC Molecular and Cell Biology 2022 23:31
    Content type: Research Published on:

  42. Mechanisms of long chain fatty acid uptake across the plasma membrane are important targets in treatment of many human diseases like obesity or hepatic steatosis. Long chain fatty acid translocation is achieve...

    Authors: Robert Ehehalt, Richard Sparla, Hasan Kulaksiz, Thomas Herrmann, Joachim Füllekrug and Wolfgang Stremmel
    Citation: BMC Cell Biology 2008 9:45
    Content type: Research article Published on:

  43. RhoA is a master regulator of cytoskeletal contractility, while nitric oxide (NO) is a master regulator of relaxation, e.g., vasodilation. There are multiple forms of cross-talk between the RhoA/ROCK pathway a...

    Authors: Akila Surendran, C. Forbes Dewey Jr, Boon Chuan Low and Lisa Tucker-Kellogg
    Citation: BMC Molecular and Cell Biology 2021 22(Suppl 1):47
    Content type: Research Published on:

    This article is part of a Supplement: Volume 22 Supplement 1

  44. Non-professional phagocytosis is usually triggered by stimuli such as necrotic cell death. In tumor therapy, the tumors often disappear slowly and only long time after the end of therapy. Here, tumor therapy i...

    Authors: Dorian Gottwald, Florian Putz, Nora Hohmann, Maike Büttner-Herold, Markus Hecht, Rainer Fietkau and Luitpold Distel
    Citation: BMC Molecular and Cell Biology 2020 21:79
    Content type: Research article Published on:

  45. The cytotoxicity and the rejoining of DNA double-strand breaks induced by γ-rays, H2O2 and neocarzinostatin, were investigated in normal and PARP-1 knockout mouse 3T3 fibroblasts to determine the role of poly(ADP...

    Authors: Georges Noël, Nicole Giocanti, Marie Fernet, Frédérique Mégnin-Chanet and Vincent Favaudon
    Citation: BMC Cell Biology 2003 4:7
    Content type: Research article Published on:

  46. Cancer cell responses to chemotherapeutic agents vary, and this may reflect different defects in DNA repair, cell-cycle checkpoints, and apoptosis control. Cytometry analysis only quantifies dye-incorporation...

    Authors: Asako Sakaue-Sawano, Tamiyo Kobayashi, Kenji Ohtawa and Atsushi Miyawaki
    Citation: BMC Cell Biology 2011 12:2
    Content type: Methodology article Published on:

  47. Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptu...

    Authors: Mauro Paradisi, Dayle McClintock, Revekka L Boguslavsky, Christina Pedicelli, Howard J Worman and Karima Djabali
    Citation: BMC Cell Biology 2005 6:27
    Content type: Research article Published on:

  48. The autosomal dominant form of Emery-Dreifuss muscular dystrophy (AD-EDMD) is caused by mutations in the gene encoding for the lamins A and C (LMNA). Lamins are intermediate filament proteins which form the nu...

    Authors: Beate Reichart, Ruth Klafke, Christine Dreger, Eleonora Krüger, Isabell Motsch, Andrea Ewald, Jochen Schäfer, Heinz Reichmann, Clemens R Müller and Marie-Christine Dabauvalle
    Citation: BMC Cell Biology 2004 5:12
    Content type: Research article Published on:

  49. A significant percentage of patients with pancreatitis often presents a history of excessive alcohol consumption. Nevertheless, the patho-physiological effect of ethanol on pancreatitis remains poorly understo...

    Authors: Marcela Fernández-Sánchez, Angel del Castillo-Vaquero, Ginés M Salido and Antonio González
    Citation: BMC Cell Biology 2009 10:77
    Content type: Research article Published on:

  50. Fibroblasts, as connective tissue cells, are able to transform into another cell type including smooth muscle cells. α1A-adrenergic receptor (α1A-AR) stimulation in rat-1 fibroblasts is coupled to cAMP production...

    Authors: Abdelwahab E Saeed, Jean-Hugues Parmentier and Kafait U Malik
    Citation: BMC Cell Biology 2004 5:47
    Content type: Research article Published on:
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