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405 result(s) for 'apoptosis' within BMC Molecular and Cell Biology

Page 3 of 9

  1. T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy in China. This study aims to explore the potential underlying mechanism...

    Authors: Xuena Yang, Xue Xiao, Lu Zhang, Bo Wang, Ping Li, Bolun Cheng, Chujun Liang, Mei Ma, Xiong Guo, Feng Zhang and Yan Wen
    Citation: BMC Molecular and Cell Biology 2022 23:4
    Content type: Research Published on:

  3. Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was to....

    Authors: Sayilaxi Jieensinue, Hong Zhu, Guangcheng Li, Keli Dong, Meiting Liang and Yayue Li
    Citation: BMC Cell Biology 2018 19:21
    Content type: Research article Published on:

  5. The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate in cu...

    Authors: Guillermo A. Videla-Richardson, Verónica A. Furmento, Carolina P. Garcia, Olivia Morris-Hanon, Gustavo E. Sevlever, Leonardo Romorini and María E. Scassa
    Citation: BMC Molecular and Cell Biology 2019 20:40
    Content type: Research article Published on:

  6. Low concentrations of carbon monoxide (CO) protect hepatocytes against apoptosis and confers cytoprotection in several models of...via their membrane permeabilization and the release of pro-apoptotic factors.

    Authors: Cláudia SF Queiroga, Ana S Almeida, Paula M Alves, Catherine Brenner and Helena LA Vieira
    Citation: BMC Cell Biology 2011 12:10
    Content type: Research article Published on:

  9. Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically altered cells due to the failure of cellular suicide progr...

    Authors: Véronique Le Mellay, Jakob Troppmair, Roland Benz and Ulf R Rapp
    Citation: BMC Cell Biology 2002 3:14
    Content type: Research article Published on:

  10. In this study we demonstrate that differentiation of human fetal neural progenitor cells under hypoxic conditions results in an increased neurogenesis. In addition, expansion and proliferation under lowered oxyge...

    Authors: Anne-Katrin Giese, Jana Frahm, Rayk Hübner, Jiankai Luo, Andreas Wree, Moritz J Frech, Arndt Rolfs and Stefanie Ortinau
    Citation: BMC Cell Biology 2010 11:94
    Content type: Research article Published on:

  12. The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.

    Authors: Natasha S Barteneva, Elizaveta Fasler-Kan, Michael Bernimoulin, Joel NH Stern, Eugeny D Ponomarev, Larry Duckett and Ivan A Vorobjev
    Citation: BMC Cell Biology 2013 14:23
    Content type: Review Published on:

  14. Dkk3 was localized to Müller glia and retinal ganglion cells in developing and adult mouse retina. Western blotting confirmed that Dkk3 is secreted from Müller glia cells in culture. We demonstrated that Dkk3 ...

    Authors: Rei EI Nakamura, Dale D Hunter, Hyun Yi, William J Brunken and Abigail S Hackam
    Citation: BMC Cell Biology 2007 8:52
    Content type: Research article Published on:

  15. Splicing variants of human cathepsinB primary transcripts (CB(-2,3)) result in an expression product product which lacks the signal peptide and parts of the propeptide. This naturally truncated Δ51CB is thus unab...

    Authors: Felix Bestvater, Claudia Dallner and Eberhard Spiess
    Citation: BMC Cell Biology 2005 6:16
    Content type: Research article Published on:

  16. The CD44+CD117+cells isolated from human epithelial ovarian cancer SKOV-3 cell line using magnetic-activated cell sorting were found to grow faster than the SKOV-3 cells in the 3D culture and in the nude mice. An...

    Authors: Junsong Chen, Jing Wang, Dengyu Chen, Jie Yang, Cuiping Yang, Yunxia Zhang, Hongyi Zhang and Jun Dou
    Citation: BMC Cell Biology 2013 14:7
    Content type: Research article Published on:

  17. Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquino...

    Authors: Aloka B. Bandara, Joshua C. Drake and David A. Brown
    Citation: BMC Molecular and Cell Biology 2021 22:35
    Content type: Research article Published on:

  18. Database search identified nonsense and missense mutations in the N-terminal TPR motifs and the C-terminal, catalytic JmjC domain, but also in the intrinsically disordered region connecting both these two well-st...

    Authors: J. Koch, A. Lang, P. Whongsiri, W. A. Schulz, M. J. Hoffmann and A. Greife
    Citation: BMC Molecular and Cell Biology 2021 22:54
    Content type: Research article Published on:

  19. Human (HIEC, Caco-2/15) IECs were exposed to specific antibodies that block the binding activity of integrin subunits (α2, α3, α5, α6, β1 or β4) to verify whether or not their inhibition induced anoikis. The knoc...

    Authors: Marco Beauséjour, Sonya Thibodeau, Marie-Josée Demers, Véronique Bouchard, Rémy Gauthier, Jean-François Beaulieu and Pierre H Vachon
    Citation: BMC Cell Biology 2013 14:53
    Content type: Research article Published on:

  20. Stanniocalcin 2 (STC2) is a secreted protein activated by (PKR)-like Endoplasmic Reticulum Kinase (PERK) signalling under conditions of ER stress in vitro. Over-expression of STC2 in mice leads to a growth-restri...

    Authors: Elena N Fazio, Gabriel E DiMattia, Sami A Chadi, Kristin D Kernohan and Christopher L Pin
    Citation: BMC Cell Biology 2011 12:17
    Content type: Research article Published on:

  21. Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degene...

    Authors: Bernadette Jeremiasse, Csaba Matta, Christopher R. Fellows, David J. Boocock, Julia R. Smith, Susan Liddell, Floris Lafeber, Willem E. van Spil and Ali Mobasheri
    Citation: BMC Molecular and Cell Biology 2020 21:47
    Content type: Research article Published on:

  22. We have directly quantitated the effect of resolving RNAi treatments at the single cell level in experimental systems for both exogenous and endogenous targets. Analyzing the effect of an siRNA that targets GFP a...

    Authors: Peter LaPan, Jing Zhang, Jing Pan, Andrew Hill and Steven A Haney
    Citation: BMC Cell Biology 2008 9:43
    Content type: Methodology article Published on:

  23. Here, we investigate the biological effects of three widely expressed alternatively spliced variants of MDM2...; MDM2-A, MDM2-B and MDM2-C, both in unstressed MCF-7 breast cancer cells and in cells subjected to c...

    Authors: Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning and Stian Knappskog
    Citation: BMC Cell Biology 2017 18:17
    Content type: Research article Published on:

  24. Second passage hUC-MSCs were cultured for multi-differentiation. Flow cytometry, qRT-PCR, von Kossa stain, alcian blue stain and oil red O stain were used for characterization and multi-differentiation determinat...

    Authors: Hao Wu, Zhanhai Yin, Ling Wang, Feng Li and Yusheng Qiu
    Citation: BMC Cell Biology 2017 18:29
    Content type: Research article Published on:

  25. We found that V-ATPase D1 was a positive regulator of YAP. Sub-lethal doses of the proton pump inhibitor esomeprazole (EMSO) in combination with paclitaxel (PTX) increased the PTX sensitivity in PTX-resistant EOC...

    Authors: Jing He, Xiao-Yan Shi, Zhi-min Li, Xiao-hua Pan, Ze-Lian Li, Ying Chen, Shi-Jie Yan and Lan Xiao
    Citation: BMC Molecular and Cell Biology 2019 20:49
    Content type: Research article Published on:

  26. In the present study, bromide does not affect cell viability and apoptosis of H9C2 cardiomyocytes. Bromide dampens the clock...Hk2 and Pkm2) gene expression rhythmicity in a dose-dependent manner. Additionally, b...

    Authors: Yicheng Jiang, Yang Gu, Hai Xu, Xiaoyi Tian, Xuefeng Zhang, Xiaojin Xu, Wenting Yan and Xiwen Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:44
    Content type: Research article Published on:

  28. Indeed, LPC and HPC can be distinguished for mitochondrial membrane potential (ΔΨm) just after isolation from the fiber. This is matched by mitochondrial redox state measured via NAD+/NADH analysis and alternativ...

    Authors: Andrea Repele, Ramona Lupi, Simon Eaton, Luca Urbani, Paolo De Coppi and Michelangelo Campanella
    Citation: BMC Cell Biology 2013 14:24
    Content type: Research article Published on:

  30. Pelota (PELO) is an evolutionary conserved protein, which has been reported to be involved in the regulation of cell proliferation and stem cell self-renewal. Recent studies revealed the essential role of PELO...

    Authors: Ozanna Burnicka-Turek, Aleksandra Kata, Byambajav Buyandelger, Linda Ebermann, Nadine Kramann, Peter Burfeind, Sigrid Hoyer-Fender, Wolfgang Engel and Ibrahim M Adham
    Citation: BMC Cell Biology 2010 11:28
    Content type: Research article Published on:

  31. Our data contribute to understanding the function of Tat in the nucleolus, where ribosomal RNA synthesis and cell cycle control take place. The impairment of nucleolar pre-rRNA maturation through the interaction ...

    Authors: Donatella Ponti, Maria Troiano, Gian Carlo Bellenchi, Piero A Battaglia and Franca Gigliani
    Citation: BMC Cell Biology 2008 9:32
    Content type: Research article Published on:

  32. Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotr...

    Authors: Eun Young Lee, You Jin Nam, Sangjin Kang, Eun Ju Choi, Inbo Han, Jinwan Kim, Dong Hyun Kim, Ji Hae An, Sunghou Lee, Min Ho Lee and Ji Hyung Chung
    Citation: BMC Molecular and Cell Biology 2020 21:42
    Content type: Research article Published on:

  33. The COP9/signalosome (CSN) is a highly conserved eight subunit complex that, by deneddylating cullins in cullin-based E3 ubiquitin ligases, regulates protein degradation. Although studied in model human cell l...

    Authors: Claire Pearce, Rachel E Hayden, Christopher M Bunce and Farhat L Khanim
    Citation: BMC Cell Biology 2009 10:31
    Content type: Research article Published on:

  34. Mutations in the A bnormal Sp indle M icrocephaly related gene (ASPM) are the commonest cause of autosomal recessive primary microcephaly (MCPH) a disorder characterised by a small brain and associated mental ret...

    Authors: Julie Higgins, Carol Midgley, Anna-Maria Bergh, Sandra M Bell, Jonathan M Askham, Emma Roberts, Ruth K Binns, Saghira M Sharif, Christopher Bennett, David M Glover, C Geoffrey Woods, Ewan E Morrison and Jacquelyn Bond
    Citation: BMC Cell Biology 2010 11:85
    Content type: Research article Published on:

  36. The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity ...

    Authors: Kristin M Slade, Sydney Freggiaro, Kyle A Cottrell, Joshua J Smith and Emily A Wiley
    Citation: BMC Cell Biology 2011 12:40
    Content type: Research article Published on:

  37. Acquisition of resistance to "anoikis" facilitates the survival of cells under independent matrix-deficient conditions, such as cells in tumor progression and the production of suspension culture cells for bio...

    Authors: Xiao-Kui Ma, Li Wang, Yu Li, Xiang-Ming Yang, Pu Zhao, HaoTang, Ping Zhu, Ling Li and Zhi-Nan Chen
    Citation: BMC Cell Biology 2010 11:27
    Content type: Research article Published on:

  38. In the present work, we further investigated the mechanisms of action of pseudopeptide N6L on angiogenesis using HUVECs. We provide evidence that N6L inhibits the in vitro adhesion, proliferation and migration of...

    Authors: Charalampos Birmpas, Jean Paul Briand, Josẻ Courty and Panagiotis Katsoris
    Citation: BMC Cell Biology 2012 13:32
    Content type: Research article Published on:

  39. Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis rem...

    Authors: Zahra Malakoutikhah, Zahra Mohajeri, Nasim Dana and Shaghayegh Haghjooy Javanmard
    Citation: BMC Molecular and Cell Biology 2023 24:5
    Content type: Research Published on:

  40. Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse mammary epithelial cells. An HC11 mammary epithelial cell line expressing...

    Authors: Bethanie L Morrison, Cynthia C Jose and Mary Lou Cutler
    Citation: BMC Cell Biology 2010 11:35
    Content type: Research article Published on:

  41. The human Obg-like ATPase 1 (OLA1) protein has been reported to play an important role in cancer cell proliferation. The molecular mechanism underlying OLA1 regulated oral metastasis is still unknown. We inves...

    Authors: Jianzhou Liu, Qing Yang, Kevin Chen Xiao, Thomas Dobleman, Shen Hu and Gary Guishan Xiao
    Citation: BMC Molecular and Cell Biology 2020 21:65
    Content type: Research article Published on:

  42. Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function ...

    Authors: Jean X. Jiang and Silvia Penuela
    Citation: BMC Cell Biology 2016 17(Suppl 1):S12
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  43. Pyroptosis of endothelial cells is a new cause of endothelial dysfunction in multiple diseases. Ceramide acts as a potential bioactive mediator of inflammation and increases vascular endothelial permeability i...

    Authors: Fangfang Liu, Yangyang Zhang, Yining Shi, Kai Xiong, Fugui Wang and Jin Yang
    Citation: BMC Molecular and Cell Biology 2022 23:54
    Content type: Research Published on:

  44. Candidate genes required for lytic reovirus infection were identified by tagged sequence mutagenesis, a process that permits rapid identification of genes disrupted by gene entrapment. One hundred fifty-one re...

    Authors: Edward L Organ, Jinsong Sheng, H Earl Ruley and Donald H Rubin
    Citation: BMC Cell Biology 2004 5:41
    Content type: Research article Published on:

  45. Our findings suggest that AKT plays a central role in upregulating glycolysis via induction of lactate dehydrogenase expression, but has no impact on glucose uptake of T cells. Furthermore, under apoptosis induci...

    Authors: Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist
    Citation: BMC Cell Biology 2016 17:28
    Content type: Research article Published on:

  46. Podocytes were incubated with PM2.5 after being pre-treated with triptolide, viability, apoptosis rate and migratory capacity of podocytes were ... dissociated cytoskeleton in podocytes, increased the podocytes apoptosis

    Authors: Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang and Yanwei Liu
    Citation: BMC Molecular and Cell Biology 2020 21:4
    Content type: Research article Published on:

  47. The retinoblastoma protein (Rb) plays a central role in the regulation of cell cycle, differentiation and apoptosis. In cancer cells, ablation of Rb...

    Authors: Ioana Ferecatu, Nathalie Le Floch, Marie Bergeaud, Aida Rodríguez-Enfedaque, Vincent Rincheval, Lisa Oliver, François M Vallette, Bernard Mignotte and Jean-Luc Vayssière
    Citation: BMC Cell Biology 2009 10:50
    Content type: Research article Published on:

  48. The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-def...

    Authors: Christopher J Armit, Shirley O'Dea, Alan R Clarke and David J Harrison
    Citation: BMC Cell Biology 2002 3:27
    Content type: Research article Published on:

  49. Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The present study investigated the effe...

    Authors: Ying Kuang, Shengwen Huang, Shifan Tang, Zhaozhen Zhuo and Keyan Linghu
    Citation: BMC Molecular and Cell Biology 2023 24:34
    Content type: Research Published on:

  50. These data implicate ATM as the PIKK that phosphorylates H2AX in response to DNA damage caused by CS. Based on current understanding of ATM activation, expression and localization, these data would suggest that, ...

    Authors: Toshiki Tanaka, Xuan Huang, Ellen Jorgensen, Diana Gietl, Frank Traganos, Zbigniew Darzynkiewicz and Anthony P Albino
    Citation: BMC Cell Biology 2007 8:26
    Content type: Research article Published on:
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